低级别胶质瘤复发、恶变中VEGF、EGFR表达的变化及意义

The changes and significance of VEGF and EGFR expression in the patients with recurrent and malignant development of low grade glioma

目的低级别胶质瘤预后的决定因素很多，但即使是相同情况下预后也可以明显不同。部分低级别胶质瘤术后很快复发，且伴有病理级别的升高，这部分病人的预后较差。本研究旨在探讨在低级别胶质瘤复发恶变中VEGF和EGFR表达的变化，并分析这些变化的意义。方法 采用免疫组化SP二步法对24对初发低级别及复发、恶变后高级别胶质瘤标本分别进行VEGF和EGFR的表达检测，分析它们在低级别胶质瘤初发和复发、恶变过程中的表达差异。结果与初发的低级别胶质瘤标本相比，VEGF、EGFR在复发、恶变后的表达率明显升高，其表达差异有统计学意义（P〈0．05）。结论 本研究表明VEGF和EGFR在低级别胶质瘤复发、恶变中起到非常重要的作用。VEGF和EGFR的表达可以作为低级别胶质瘤预后的指标之一，并为今后胶质瘤的靶向治疗提供理论依据。

Objective There are many factors associated with the prognosis of the patients with low grade gliomas （LGG）. In some cases, the prognosis of the patients with low grade glioma differ completely, althrough using the same treatment. Some of the patients with LGG soon reccured after operation ,following by malignant development. The prognosis of these patients was very poor. This stduy was to detect the changes and significance of VEGF and EGFR expression in the patients with recurrent and malignant development of low grade glioma. Methods The expressions of VEGF and EGFR in 24 pairs of cases with primary LGG as well as recurrent and malignant development were examined by using immunohistoehemieal SP method. The different expressions of VEGF and EGFR in the patients with LGG as well as recurrent and malignant development were analyzed. Results The expressions of VEGF and EGFR in the patients with recurrent and malignant development were significant- ly increased, compared with the patients with primary LGG （ P 〈 0.05 ）. Conclusions The expressions of VEGF and EGFR played an important role in the patients with recurrent and malignant development of low grade gliomas. The expressions of VEGF and EGFR may he used as an indicator of poor prognosis for the patients with low grade glioma. It also provided a theroic basis of target therapy for the patients with glioma.