血管紧张素转化酶2的生理和病理作用
摘要
肾素-血管紧张素系统（RAS）通过对心脏、血管和肾脏的调节，维持血压、体液和电解质的平衡。异常的RAS激活与心血管和肾脏疾病的发生紧密相关，如高血压、心肌梗死、糖尿病肾病等。多年来血管紧张素转化酶（ACE）一直被认为是调节RAS的关键酶。
出处
《包头医学院学报》
CAS
2012年第3期120-121,共2页
Journal of Baotou Medical College
参考文献10
-
1Imai Y,Kuba K,Rao S. Angiotensin converting enzyme 2 protects from severe acute lung failure[J].Nature,2005.112-116.
-
2Zhang Y,Wada J. Collectrin,a homologue of ACE2,its transcriptional control and functional perspectives[J].Biochemical and Biophysical Research Communications,2007.1-5.
-
3Li W,Moore MJ,Vasilieva N. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus[J].Nature,2003.450-454.doi:10.1038/nature02145.
-
4Fan X,Wang Y,Sun K. Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women[J].Clinical Pharmacology and Therapeutics,2007.187-196.
-
5Grobe JL,Der SS,Stewart JM. ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts[J].Clinical Science(London),2007.357-364.
-
6Der SS,Grobe JL,Yuan L. Cardiac overexpression of angiotensin-converting enzyme 2 protects the heart from ischemia-induced pathophysiology[J].Hypertension,2008.712-718.
-
7Jerng JS,Yu CJ,Wang HC. Polymorphism of the angiotensin-converting enzyme gene affects the outcome of acute respiratory distress syndrome[J].Critical Care Medicine,2006.1001-1006.
-
8Ferreira AJ,Shenoy V,Yamazato Y. Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension[J].American Journal of Respiratory and Critical Care Medicine,2009.1048-1054.doi:10.1164/rccm.200811-1678OC.
-
9Ferreira AJ,Shenoy V,Yamazato Y. Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension[J].American Journal of Respiratory and Critical Care Medicine,2009.1048-1054.doi:10.1164/rccm.200811-1678OC.
-
10Zhang R,Wu Y,Zhao M. Role of HIF-1alpha in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells[J].American Journal of Physiology-Lung Cellular and Molecular Physiology,2009.L631-L640.
-
1徐丽,陈兰英.利钠肽结构、受体的生理和病理作用[J].中国病理生理杂志,2004,20(8):1517-1521. 被引量：13
-
2黄碧霞,叶钦勇.NOX2与中枢神经系统关系的研究进展[J].国际神经病学神经外科学杂志,2012,39(2):187-191.
-
3宋春梅,王长文,马洪波,李质馨.大鼠体内ET和NO水平与衰老的关系[J].吉林大学学报（医学版）,2003,29(3):373-373.
-
4唐省三.一氧化氮的生理和病理作用[J].四川生理科学杂志,2002,24(3):108-111. 被引量：13
-
5温绍君,刘洁琳.血管内皮细胞功能研究概况[J].生殖医学杂志,2005,14(5):310-313. 被引量：15
-
6王娜,邢小燕.低钠血症的研究进展[J].中国医刊,2011,46(6):28-30. 被引量：1
-
7李国逊,李宁.Toll样受体对肠屏障是起保护作用还是损害作用[J].中华胃肠外科杂志,2009,12(5):540-541. 被引量：3
-
8薛同敏,张培建,刘霞,朱世春.低氧诱导因子在肿瘤中的表达及其意义[J].中华临床医师杂志（电子版）,2013,7(10):152-153. 被引量：3
-
9彭晓晖,周总光.胰腺局部组织肾素-血管紧张素系统研究进展[J].消化外科,2003,2(2):148-150.
-
10赵学芹,黄宪章.Akt/PKB信号通路调控机制的研究进展[J].广东医学,2009,30(12):1920-1922. 被引量：11
