期刊文献+

培美曲塞维持治疗非小细胞肺癌30例的疗效观察 被引量:1

下载PDF
导出
摘要 目的观察培美曲塞维持治疗非小细胞肺癌(NSCLC)的临床效果。方法将60例NSCLC患者随机分为观察组和对照组,每组30例,两组均接受常规化疗。第6周期化疗结束后,观察组接受培美曲塞维持治疗,评估两组的临床效果。结果观察组患者无进展生存期及生存时间明显高于对照组[分别为(7.35±1.10)vs(3.56±1.12)月,(9.03±1.13)vs(6.69±1.13)月,均P<0.01],疗效也优于对照组(Hc=4.7102,P<0.05)。两组不良药物反应发生情况差异无统计学意义(P>0.05)。结论培美曲塞维持治疗非小细胞肺癌的临床效果明确,毒副作用少,值得应用。
出处 《广东医学院学报》 2012年第2期188-189,共2页 Journal of Guangdong Medical College
  • 相关文献

参考文献4

二级参考文献32

  • 1Non-small Cell Lung Cancer Collaborative Group.Chemotherapy in Non-small Cell Lung Cancer:a Meta-analysis Using Updated Data on Individual Patients from 52 Randomised Clinical Trials[J].BMJ,1995,311:899-909.
  • 2Bunn P A.Chemotherapy for Advanced Non-small-cell Lung Cancer:Who,What,When,Why?[J].J Clin Oncol,2002,20(18):23-33.
  • 3Goldie J H,Coldman A J.A Mathematical Model for Relating the drug Sensitivity of Tumors to Their Spontaneous Mutation Rate[J].Cancer Treat Rep,1979,63(11/12):1727-1733.
  • 4Smith I E,O'Brien M E,Talbot D C,et al.Duration of Chemotherapy in Advanced Non Small-cell Lung Cancer:a Randomized Trial of Three Versus Six Courses of Mitomycin,Vinblastine,and Cisplatin[J].J Clin Oncol,2001,19(5):1336-1343.
  • 5Ciuleanu T E,Brodowicz T,Belani C P,et al.Maintenance Pemetrexed Plus Best Supportive Care (BSC) Versus Placebo Plus BSC:a Phase Ⅲ Study[J].J Clin Oncol,2008,26(S0):8011.
  • 6Hida T,Okamoto I,Kashii T,et al.Randomized Phase Ⅲ Study of Platinum-doublet Chemotherapy Followed by Gefitinib Versus Continued Platinum-doublet Chemotherapy in Patients (pts) with Advanced Non-small Cell Lung Cancer (NSCLC):Results of West Japan Thoracic Oncology Group trial (WJTOG)[J].J Clin Oncol,2008,26(S0):8012.
  • 7Cappuzzo F,Ciuleanu T,Stelmakh L,et al.A double-blind,Randomized,Phase Ⅲ Study of Maintenance Erlotinib Versus Placebo Following Non Progression with First-line Platinum-based Chemotherapy in Patients with Advanced NSCLC[J].J Clin Oncol,2009,27(S0):8001.
  • 8Demarinis F,Paul S,Hanna N,et al.Survival Update for the Phase Ⅲ Study of Pemetrexed vs Docetaxel in Non-small Cell Lung Cancer(NSCLC)[J].J Clin Oncol,2006,24(S0):7133.
  • 9Calvert H.An overview of folate metabolism:Features relevant to the action and toxicities of antifolate anticancer agents[J].Semin Oncol,1999,26(2Suppl6):3.
  • 10Rollins KD,Lindley C.Pemetrexed:a multitargeted antifolate[J].Clin Ther,2005,27(9):1343-1382.

共引文献32

同被引文献15

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部