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线粒体功能与谷氨酸信号在胰岛素分泌中的作用

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摘要 葡萄糖诱导胰岛素分泌是由线粒体产生的信号来决定的。机体内胰腺β细胞线粒体的功能及谷氨酸信号的传导在胰岛素的分泌中有重要的作用,一旦线粒体功能出现异常将对谷氨酸信号的传导造成影响进而导致胰岛素分泌机制异常,这与糖尿病的发生密切相关。因此,研究线粒体功能与谷氨酸信号在胰岛素分泌调节中的作用有利于更进一步了解糖尿病的发病机制,从而为治疗糖尿病提供有利的线索。该文主要对线粒体功能与谷氨酸信号在胰岛素分泌方面的研究进行了综述。
机构地区 广东医学院
出处 《广东医学院学报》 2012年第2期200-201,共2页 Journal of Guangdong Medical College
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参考文献17

  • 1Maechler P, Kennedy E D, Wollheim C B, et al. Mitochon-drial activation directly triggers the exoeytosis of insulin in permeabilized pancreatic β ceUs[J]. EMBO Journal, 1997, 16, 3833-3841.
  • 2Koeck T, Olsson A H, Nitcrt M D, et al. A common variant in TFB 1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes[J]. Cell Mctab, 2011, 13(1): 80-91.
  • 3Li X L, Chen T, Wong Y S, et al. Involvement of mitochond-rial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-IE pancreatic beta cells: an effect attenuat-ed by phycocyanin[J]. Int I Biochem Cell Biol, 201 1, 43(4): 525-534.
  • 4Fex M, Dekker M N, Wierup N, et al. Enhanced mitochond-rial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet[J]. Diabetologia, 2007, 50(1):74-83.
  • 5Maechler P, Antinozzi P A, Wollheim C B, et al. Modulation of glutamate generation in the mitochondria affects hormone secretion in INS-1E beta cells[J]. IUBMB Life, 2000, 50:27-31.
  • 6Maechler P, Kennedy E D, Wollheim C B, et al. Desensitiza-tion of 2+ mitochondrial Ca and insulin secretion responses in the beta cell[J]. J Biol Chem, 1998, 273(33):20770-20778.
  • 7Pongratz R L, Kibbey R G, Shulman G I, et al. Cytosolic and mito- chondrial malic enzyme isoforms differentially control insulin secre- tion[J]. J Biol Chcm, 2002, 282(1): 200-207.
  • 8Maechler P, Carobbio S, Rubi B, et al. In beta-cells, mito-chondria integrate and generate metabolic signals controlling insulin secretion[J]. Int J Biochem Cell Biol, 2006, 38(5-6): 696-709.
  • 9Maechler P, Jomot L, Wollheim C B, et al. Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells[J]. J Biol Chem, 1999, 274(39): 27905-27913.
  • 10Frigerio F, Casimir M, Carobbio S, et al. Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis [J]. Biochimica et Biophysiea Acta (BBA), 2008, 1777 (7-8): 965-972.

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