膀胱副神经节瘤2例报告并文献复习

Two cases reports and literature review of bladder paraganglioma

目的探讨膀胱副神经节瘤的临床病理及免疫组化特征。方法对2铡膀胱副神经节瘤进行组织病理学观察及免疫组化分析并复习文献。结果2例大体肿物均有完整包膜。镜下肿瘤细胞排列呈巢状及条索状，其中l例伴有鳞状细胞或腺样分化的器官样结构。细胞大小不等，细胞核圆形、椭圆形、梭形，核分裂罕见。瘤细胞巢间有丰富的大、小血窦。免疫组化瘤细胞CgA、Syn、S-100阳性，CK、CK7、HMB45、CEA阴性。结论膀胱副神经节瘤是较罕见的肿瘤，诊断依赖于组织病理形态及免疫组化。

Objeclive To study the histopathologieal and immunohistochemical characteristic of bladder paraganglio-ma. Methods Two eases of bladder paragangliomas were observed on histopathology and had an immunohistochem-ieal analysis, and related literatures were reviewd. Results Grossly, tumor margins were confined within the cap-sule. The tumor cells disposed in cords, solid cell nests or clusters,one with squamous or glandular organization in one case. They were different in cells size. Nucleus were usually exhibited round, orbicular ovate or fusiform, and nuclear fission were rare. Blood sinus were affluent in stroma.Immunohistochemical study demonstrated that tumor cell were acted with CgA , Syn and S100, but negatively with CK, CK7, HMB45 and CEA. Conclusions Bladder paraganglioma is a rarely tumor that its diagnosis depended on histopathologieal observation and immunohistoehemi-cal staining.