复方水杨酸洗剂药效学研究

Experimental Research of Pharmacodynamics for Compound Salicylic Acid Lotion

目的研究复方水杨酸洗剂抗炎镇痛的药效作用,为该药的临床研究提供基础。方法采用2种致痛动物模型和2种炎症动物模型,观察不同剂量的复方水杨酸洗剂对实验性动物的镇痛作用和抗炎作用,并与曲安奈德溶液进行对比试验。结果复方水杨酸洗剂能提高热板法致痛模型小鼠的痛阈,减少电刺激致痛的发生率,有效抑制二甲苯引起的小鼠耳廓炎症肿胀和毛细血管通透性,并均呈现良好的量效依赖关系。在相同剂量下,复方水杨酸洗剂镇痛效果优于曲安奈德溶液(P<0.01),抗炎作用与曲安奈德溶液相似。结论复方水杨酸洗剂能改善皮肤疾病的疼痛和水肿渗出症状。

Objective To research the effect of anti- inflammatmatory and analgesia effect for Compound Salicylic Acid Lotion（CSAL）. Methods Using 2 kinds of pained animal models and 2 kinds of inflammatory animal models to research the treating effects, and comparing with Triamcinolone Solution. Results CSAL can improve the threshold of pain made by hot iron plate, and can reduce the ratio of pain made by electrical stimulation,and can restrain permeability of capillary vessels and tumefaction made by Xylene. In the same dosage,the effect of analgesia of CSAL was significantly better than Triamcinolone Solution（P 〈 0.01）,and the effect of anti-inflammatory was similar with Triamcinolone Solution. Conlusions CSAL can ameliorate the symptoms of pain and oedema, and provide an experimental basis for clinical application.