期刊文献+

辛伐他汀强化降脂治疗对急性冠脉综合征预后的影响 被引量:3

下载PDF
导出
摘要 目的分析小剂量、大剂量辛伐他汀降脂治疗对急性冠脉综合征(ACS)预后的影响。方法将医院收治的120例ACS患者分为3组,分别给予小剂量、大剂量辛伐他汀治疗以及不予辛伐他汀治疗,治疗1个月后观察各项指标及追访和统计缺血事件发生率。结果辛伐他汀治疗1个月后,小剂量及大剂量组的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP)与治疗前比较均降低(P<0.05),小剂量组与大剂量组比较,差异有统计学意义(P<0.05);小剂量组与大剂量组的缺血性事件的发生率明显降低。结论临床应用辛伐他汀强化降脂治疗ACS可调节血脂及减轻炎性反应,减少急性冠脉事件的发生,但大剂量强化降脂在本研究中未显示明显优势。
作者 方柯
出处 《中国药业》 CAS 2012年第11期84-85,共2页 China Pharmaceuticals
  • 相关文献

参考文献6

二级参考文献25

共引文献16

同被引文献36

  • 1Ranoof MA, lqbalk, Miy MM ,et al. Measurement of plasma lipids inpa- tients admitted with acute myocardial infarction or unstable angina pee- toffs[ J]. Am J Cardid,2001,88 : 165 167.
  • 2Wiviott SD,De Lemos JA,Cannon CP,et al. A tale of two trials:a com- parison of the post-acute coronary syndrome lipid-lowering trials A to Z and PROVE IT-TIMI 22 [ J ]. Circulation, 2006, 113 ( 11 ) : 1406 1414.
  • 3Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol - lowering treatment : prospective meta - analysis of data from 90,056 participants in 14 randomised trials of statins[J]. Lancet, 2005,366(9 493 ): 1 267 - 1 278.
  • 4Cholesterol Treatment Trialists' (CTT) Collaborators, Kearney PM, Black- well L, et al. Efficacy of cholesterol -lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis[J]. Lancet, 2008,37 (9 607) : 117 - 125.
  • 5Carmena R, Duriez P, Fruchart JC. Atherogenic lipoprotein particles in atherosclerosis [ J ]. Circulation, 2004,109 (3) : 2 - 7.
  • 6St- Pierre AC, Cantin B, Dagenais GR, et al. Low- density lipoprotein subfractions and the long -term risk of ischemic heart disease in men: 13- year follow- up data from the Qu6bee Cardiovascular Study[J]. Arterioscler Thromb Vasc Biol, 2005,25 (3) : 553 - 559.
  • 7Hirano T, Ito Y, Yoshino G. Measurement of small dense low - density lipoprotein particles [ J ]. J Atheroscler Thromb, 2005,12 ( 2 ) : 67 - 72.
  • 8Rizzo M, Barbagallo CM, Severino M, et al. Low - density - lipoprotein peak particle size in a Mediterranean population[J]. Eur J Clin Invest, 2003,33(2) : 126 - 133.
  • 9Vaverkova H, Karasek D, Novotny D, et al. Apolipoprotein B versus LDL - cholesterol:Association with other risk factors for atherosclerosis[J]. Clin Biochem, 2009,42 (12) : 1 246 - 1 251.
  • 10Onat A, Can G, Cicek G, et al. Predictive value of serum apolipoprotein B/LDL - cholesterol ratio in cardiometabolic risk : population - based co- hort study[J]. Cliu Biochem,2010,43(18) :1 381 - 1 386.

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部