二甲双胍和阿卡波糖治疗早期糖尿病肾病疗效比较

Comparison of effect between Metformin and Acarbose in treatment of type 2 diabetes mellitus with early diabetic nephropathy

目的比较二甲双胍和阿卡波糖对早期糖尿病肾病的疗效。方法将122例2型糖尿病早期糖尿病肾病患者随机分为二甲双胍组和阿卡波糖组，二甲双胍组58例口服二甲双胍片。阿卡波糖组59例口服阿卡波糖片，疗程24周，观察两组治疗前后的血压（BP）、空腹血糖（FPG）、稳态模型胰岛素抵抗指数（HOMA_IR）、糖化血红蛋白（HbAle）、血清高敏C反应蛋白（Hs-CRP）、尿白蛋白排泄率（UAER）的变化。结果两组FPG、HbAle均有明显下降，但在降低BP、HOMA-IR、Hs—CRP、UAER方面二甲双胍组优于阿卡波糖组。结论对于2型糖尿病早期糖尿病肾病的患者，二甲双胍较阿卡波糖可更有效地降低UAER。

Objective To compare the effects of metformin and acarbose for early diabetic nephropathy. Methods 122 cases of type 2 diabetic mellitus（T2DM） with early diabetic nephropathy were randomly devided into Metformin group including 58 cases treated with Metformin and Acarbose group including 59 cases treated with Acarbose for 24 weeks. Two groups＂ parameters including blood pressure（BP）, fasting glucose （ FPG）, glycosylated hemoglobin C （HbAlc）, HOMA-IR, high sensitivity C-reactive protein （Hs-CRP） and urinary albumin excretory rate（UAER） were observed before and after therapy. Results FPG and HbAlc were significantly declined in both groups. Compared with Acarbose group,BP, HOMA-IR, Hs-CRP, UAER were significantly decreased in Metformin group. Con- elusion For the T2DM with early diabetic nephropathy,Metformin can reduce UAER better than Aearbose.