低剂量丙酸倍氯松吸入对轻度哮喘儿童气道高反应性的影响

Effect of beclomethason dispropionate at a low dose on bronchial hyperresponsiveness in children with mild asthma

为探讨低剂量丙酸倍氯松(BDP)吸入对轻度哮喘儿童肺功能及气道高反应性(BHR)的影响,将30例轻度哮喘患儿随机分为3组,分别吸入安慰剂、BDP200μg/d或400μg/d。结果:患儿吸入200μg/d或400μg/d BDP后,哮喘症状及肺功能明显改善,BHR显著下降,各项指标变化在200μg组及400μg组间无显著差异。结论:每天吸入200μgBDP即能有效控制轻度儿童哮喘的临床症状,改善其肺功能并降低BHR,将剂量增加至400μg/d并不能明显增加疗效。建议使用BDP吸入疗法治疗轻度儿童哮喘时,常规剂量宜采用200μg/d。

To explore the effect of beclomethason dispropionate (BDP) at a low dose on bronchial hyperresponsiveness (BHR) in children with mild asthma, 30 cases were randomly assigned as control group (10 cases, just placebo), 200μg group (10 cases, BDP 200μg/d) and 400μg group (10 cases, BDP 400μg/d), respectively. The results showed that BHR decreased significantly and the lung function and clinical symptoms improved obviously in either 200μg or 400μg groups comparing with the control group, although no significant difference was observed between 200μg and 400μg groups. It is concluded that BDP at a lower dose of 200μg can control the clinical asthmatic symptoms, improve lung function and decrease BHR. It is suggested that 200μg/d of BDP should be as a routine dose for the treatment of mild asthmatic children.