阻塞性睡眠呼吸暂停低通气综合征对急性脑梗死患者认知功能的影响

Effects of obstructive sleep apnea on cognitive function of patients with acute cerebral infarction

目的探讨阻塞性睡眠呼吸暂停对急性脑梗死患者认知功能的影响。方法共纳入急性脑梗死患者64例，根据睡眠呼吸暂停低通气指数（AHI）分为非OSAS组（30例）、轻度OSAS组（15例）、中重度OSAS组（19例）。用简易智能筛查（minimentalstateexamination，MMSE）、画钟试验（clockdrawingtask，CDT）、听觉事件相关电位（P300）进行认知功能的评价，并进行组间的比较。结果中重度OSAS组MMSE、CDT评分低于非OSAS组、轻度OSAS组，其差异有统计学意义（P〈O．05）。根据MMSE及CDT结果，认知功能障碍者占的比例，中重度OSAS组高于轻度OSAS组，轻度OSAS组高于非0SAS组，且Pd0．05．P300结果显示：非0SAS组、轻度0SAS组、中重度组OSAHS组各部位的潜伏期逐渐延长，且各组间差值有统计学意义（P〈O．05）。结论急性脑梗死患者睡眠呼吸暂停严重程度与认知功能障碍相关，睡眠呼吸暂停可加重急性脑梗死者的认知功能障碍。

：Objective To investigate the effects of obstructive sleep apnea on cognitive function of patients with acute cerebral infarction. Methods A total of 64 patients with acute cerebral infarction was divided into non-OSAS group （30 cases }, mild OSAS group （15 cases }, moderate to severe OSAS group（19 cases l, according to sleep apnea-hypop- nea index（ A HI ）. Intelligent use of simple screening（ minimental state examination, MMSE ）, clock drawing test （ clock draw ing task, CDT }, auditory event related potentials （ P300 ） for the evaluation of cognitive function, and compared between groups. Results In severe OSAS group MMSE, CDT scored lower than non-OSAS group, mild OSAS group, the differences were statistically significant（ P^0.05 ）. According to the results of MMSE and CDT, cognitive dysfunction accounted for the proportion of moderate to severe OSAS group than in the mild OSAS group,mild OS- AS group than non-OSAS group,P〈0.05. P300 results：non-OSAS group,light degree of OSAS group, in the se- vere group OSAHS group all parts of the gradual extension of the incubation period, and the difference between the groups was statistically significant（P〈0.05）. Conclusions Acute stroke patients with sleep apnea severity of cogni- tive dysfunction associated sleep apnea may increase acute cerebral infarction cognitive dysfunction.