持续性高通量血液滤过治疗脓毒性休克疗效分析

Treatment efficacy of continuous high flux hemofiltration in septic shock

目的研究持续性高通量血液滤过（HV-CVVH）治疗脓毒性休克的临床疗效。方法将100例脓毒性休克患者随机分为对照组和治疗组，每组50例。两组均常规治疗，治疗组在常规治疗基础上加用HV-CVVH治疗，比较两组患者治疗前后呼吸频率（RR）、心率（HR）、平均动脉压（MAP）、APACHEII评分、血尿素氮（BUN）、血肌酐（Scr）、氧合指数（PaO2／FiO2）、血小板计数、血乳酸水平、血管活性药物使用时间的变化。结果治疗组各观察指标与对照组比较差异有统计学意义（P〈0．05）。结论在常规治疗的基础上联合HV-CVVH治疗脓毒性休克能有效改善患者的血流动力学、氧合，维持内环境稳定。

Objective To study the treatment efficacy of continuous high flux hemofiltration in septic shock. Methods 100 septic shock patients were randomly divided into control group and treatment group. The control group received the convertional therapy, and the treatment group accepted the convertional therapy and continuous high flux hemofiltration. Before and after treatment, compared with the differences of respiratory rate （RR}, heart rate （HR）, mean arterial pressure （MAP）, APACHE II score, blood urea nitrogen （BUN）, serum creatinine （Scr）, oxygenation index （PaO2/FiO2 ）, platelet count, blood lactate levels, time changes of vasoactive drugs of patients in the two groups. Results The difference of outcome measure was statistically significant（P〈0.05）. Conelmion：Combination the convertional therapy and continuous high flux hemofiltration can effectively improve the patient＇s hemodynamic and oxygenation, and maintain patient＇s homeostasis.