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右美托咪定鼻腔给药用于鼻内窥镜手术的临床观察

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摘要 目的研究右美托眯定(Dex)鼻腔给药对鼻内窥镜手术全麻效果及控制性降压的影响。方法60例ASAI或Ⅱ级接受鼻内窥镜手术的患者,随机分为两组:鼻腔给药(Dex)联合全麻组(A组)、单纯全麻组(B组)。以调节瑞芬太尼丙泊酚静脉输注速度为主要维持全麻和控制性降压的手段。A组于麻醉诱导前15min经鼻滴入Dex1t'g/kg。B组单纯全麻。比较两组达到同样地降压目标和全麻深度所需全麻用药量、血管活性药应用率、气管插管及拔管时的心血管反应、苏醒期疼痛程度及躁动发生率。结果A组所需全麻药用量血管活性药使用率、气管插管和拔管时心血管反应及苏醒期疼痛和躁动发生率均明显低于B组(P〈0.01)。结论Dex鼻腔给药可降低全麻用药量,能有效达到降压目标,减少气管插管及拔管的心血管反应,提高患者苏醒期舒适度。
出处 《中国误诊学杂志》 CAS 2012年第16期4216-4217,共2页 Chinese Journal of Misdiagnostics
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