分娩镇痛对产妇血清IL-6、IL-8、IL-10水平的影响

Effect of analgesia with continued epidural block on the serum IL-6, IL-8 and IL-10 in parturients

目的观察应用罗哌卡因连续硬膜外阻滞麻醉进行分娩镇痛对产妇血清中IL-6、IL-8、IL-10的影响。方法选择200例产妇随机分为观察组（I组）和对照组（Ⅱ组），每组100例。工组在宫口开至2～3cm时开始采用连续硬膜外阻滞麻醉方法进行分娩镇痛；Ⅱ组按产科常规处理。观察分娩镇痛前30rain、分娩镇痛后2h、分娩后24h、48h和72h五个时点患者血清中自细胞介素-6（IL-6）、白细胞介素-8（1L-8）、白细胞介素-10（IL-10）水平的变化。结果两组患者分娩镇痛后血清IL-6,IL-8、IL-10水平与分娩镇痛前值比较均升高（P〈0．01）。一般在分娩后24h达峰值。比较血清IL-6、IL-8、IL-10浓度变化。Ⅱ组较Ⅰ组升高更为明显（P〈O．05）。结论应用罗哌卡因连续硬膜外阻滞麻醉进行分娩镇痛可有效地降低产妇分娩后炎性应激反应。

Objective To observe the effect of labor analgesia with continued epidural block on the serum IL-6, IL-8 and IL-10 in parturients. Methods Two hundreds of labor women were divided into two groups with 100 cases each. One hundred parturients were selected as labor analgesia group{ groupI} and the others were as nature delivery group without analgesia （groupii）. Analgesia was used while utero-cervical was opened to 2-3 cm. The levels of serum interleukin-6 ,interleukin-8 and interleukin-10 were observed at five time points： before labor analgesia , at 2h after the labor analgesia , at 24 ,48 ,72h at the end of delivery. Results The levels of serum IL-6,1L-8 and IL-10 in- creased significantly after labor analgesia , reached at peak values at 24 h （P〈0.05 } , and then gradually declined but still than the baseline values. The serum IL-6 ,II.-8 and IL-10 were significantly higher at 2 and 24 h in groupl- Ithan those in groupI （P〈0.05} . Conclusion Labor analgesia with continued epidurai block is safe and effective . Epidural analgesia can reduce the level of serum interleukin-6,interleukin-8 and interleukin-10 and inflammatory re- sponse during delivery.