摘要
目的探讨替莫唑胺联合小剂量缓激肽对胶质瘤的治疗作用。方法立体定向法建立大鼠C6胶质瘤模型，MRI检测胶质瘤生长情况。观察常规使用替莫唑胺及替莫唑胺联合小剂量缓激肽后C6胶质瘤大鼠的生存情况，不同组别大鼠的生存期进行统计学分析。结果替莫唑胺可以有效延长C6胶质瘤大鼠的生存期，联合小剂量缓激肽后C6胶质瘤大鼠的生存期延长更显著。结论替莫唑胺对胶质瘤有治疗作用，小剂量缓激肽可以选择性开放血脑屏障，替莫唑胺联合小剂量缓激肽可以有效治疗胶质瘤，延长大鼠生存期。
Objective To investigate the effect of Temozolomide combined with low dose Bradykinin for glioma therapy. Methods To use the stereotactic method to establish the C6 glioma model rats,and test the glioma growth by MRI. Observerd the survival condition of the models treated with Temozolomide and Temozolomide with low dose Bradykinin,studied the survival times in different groups by statistical analysis. Results Temozolomide could pro- long the survival times of the models, and prolonged more signally after treated with low dose Bradykinin. Conclusion Temozolomide has curative effect for glioma,low dose Bradykinin can open blood brain barrier,temozolomide combined with low close Bradykinin can treat glioma effectively,prolong the survival times of the rat models.
出处
《中国误诊学杂志》
CAS
2012年第17期4483-4485,共3页
Chinese Journal of Misdiagnostics
