手足口病合并病毒性脑炎患儿血清中NSE及S-100B的检测价值

Clinical value on NSE and S-IOOB of serum in children with hand-foot-mouth diseases combined with viral encephalitis

目的探讨手足口病（HFMD）合并病毒性脑炎（VE）患儿血清中神经烯醇化酶（NSE）及星形胶质原性蛋白（S-100B）表达的临床意义。方法收集确诊的62例手足口病合并病毒性脑炎息儿作为观察组，收集50例排除中枢神经系统疾病的单纯手足口病患儿作为对照组，收集体检证实为正常的儿童血清标本50例作为正常对照组，对三组血清进行NSE和S-100B的测定。结果观察组患儿血清中NSE和5-100B明显高于对照组和正常对照组，对照组患儿血清中NSE和S-100B明显高于正常对照组。观察组患儿血清中NSE和S,-100B的含量与是否伴有惊厥密切相关。观察组患儿血清中NSE与S-100B的表达呈正相关。结论NSE和S-100B在手足口病合并病毒性脑炎患儿血清中高表达，在疾病的发生发展中有重要促进作用，联合检测NSE和S-100B的表达可能是早期判断脑组织损伤的客观指标之一，对于早期识别危重病例有重要价值。

Objective To detect the expresions of NSE and S-100B of serum in children with hand-foot-mouth diseases eompbined with viral encephalitis, and investigate their clinical significance. Methods 62 children with hand-foot- mouth diseases compbined with viral encephalitis were observed as observation group, 50 children with hand-foot- mouth which eliminated central nerous system disease were observed as control group,S0 normal children were ob- served as normal control group. The expressions of NSE and S-100B were detected in the three groups. Results The expressions of NSE and S-100B were obviouslyhigher in the observation group than in the other groups. The expres- sions of NSE and S-100B were obviously correlated with convulsion in the observation group. There were positively correlated between NSE and S-100B in the observation group. Conclusion The higher expressions of NSE and S- 100B can induce the development of hand-foot-mouth diseases compbined with viral encephalitis. The combined ex- amination of NSE and S-100B may be helpful to predict the pathological degree in hand-foot-mouth diseases.