双歧三联活菌胶囊、奥替溴铵、复方谷氨酰胺肠溶胶囊联合氟哌噻吨美利曲辛治疗腹泻型肠易激综合征临床疗效观察

Observation of therapeutic effect of diarrhea predominant irritable bowel syndrome treated by combination of Birid Triple Viable, Otilonium Bromide tablets, Compound Glutamin Entresoluble capsules and Flupentixol Melitracen tablets

目的观察双歧三联活菌胶囊、奥替溴铵、复方谷氨酰胺肠溶胶囊联合氟哌噻吨美利曲辛（帕罗西汀）治疗腹泻型肠易激综合征患者的临床疗效。方法120例门诊IBS-D患者随机分为A、B、C三组：A组双歧三联活菌胶囊、奥替溴铵、复方谷氨酰胺肠溶胶囊联合氟哌噻吨美利曲辛；B组双歧三联活菌胶囊、奥替溴铵、复方谷氨酰胺肠溶胶囊联合谷维素；C组普通治疗组双歧三联活菌胶囊、奥替溴铵、复方谷氨酰胺肠溶胶囊。治疗4周观察疗效，记录消化道症状评分（腹痛时间、频率；大便量、大便性状及次数改变）。结果治疗后各组症状评分均有下降（P〈0．05）．且三组有效率两两比较差异有统计学意义（P〈O．05）。结论双歧三联活菌胶囊、奥替溴铵、复方谷氨酰胺肠溶胶囊联合氟哌噻吨美利曲辛治疗腹泻型肠易激综合征更有效，值得临床推广。

Objective To observe the therapeutic effect of diarrhea predominant irritable bowel syndrome treated by combination of Birid Triple Viable, Otilonium Bromide tablets, Compound Glutamin Entresoluble capsules and Flu- pentixol Melitracen tablets. Methods 120 patients with diarrhea predominant irritable bowel syndrome were ran- domly divided into three groups, they were A group, B group, C group. 40 cases in control group were treated by Birid Triple Viable, Otilonium Bromide tablets, Compound Glutamin Entresoluble capsules. 40 patients in control group were treated by Birid Triple Viable, Otilonium Bromide tablets, Compound Glutamin Entresoluble capsules and Oryzanol. 40 cases in treatment group were treated by Birid Triple Viable, Otilonium Bromide tablets, Compound Glutamin Entresoluble capsules and Flupentixol Melitracen tablets. The effect and side effect were observed after a course（4 weeks）. Results A group,B group and C group were statistically significant difference in efficiency（P〈 0.05）. By each group pairwise comparisons between treatments, A group, B group and C group had significant differ- ences （ P〈0.05 ）. The total effective rate in treatment group（ 95.0 % ） was higher than that in control group（82.5 %, 62.5 %, P〈0.05 ）. The tolerance and safety of medicine in three groups was good. There was no obvious side effect. Conclusion The effect of combination of Birid Triple Viable, Otilonium Bromide tablets, Compound Glutamin En- tresoluble capsules and Flupentixol Melitracen tablets is definite on diarrhea predominant irritable bowel syndrome.