尿白三烯E4、IgE与外周血嗜酸性粒细胞检测对毛细支气管炎预后预测的意义

Significance of Urinary leukotriene E4, Immunoglobulin E and peripheral blood eosinophil count in predicting the prognosis of bronchiolitis

目的通过检测毛细支气管炎患儿尿白三烯E4（LTEa）、免疫球蛋白E（IgE）及外周血嗜酸性细胞计数，探讨对于毛细支气管炎预后预测的意义。方法对62例毛细支气管炎患儿急性期、恢复期及30例对照组进行有尿LTE4测定，同时检测IgE、嗜酸性粒细胞计数（EC）。预后，将62例毛细支气管炎患儿分两组，一组给予盂鲁司特治疗，另一组为对照组。三个月后观测两组患儿再次喘息发作例数。结果毛细支气管炎急性期、恢复期LTE4、IgE较对照组明显升高（P均〈0．01）．且两者具有同步性。毛细支气管炎EC急性期和恢复期与对照组无差异性（P〉0．05）。给予孟鲁司特治疗组三个月内再次发病率明显低于对照组。结论白三烯、IgE是影响毛细支气管炎患儿发病的重要炎症介质，两者都可作为预测高危哮喘转为哮喘的客观指标；外周血EC不能完全反应毛细支气管炎患儿气道炎症。口服盂鲁司特可达到早期干预的效果，从而减少哮喘的发病率。

Objective To explore the significance of urinary leukotriene E4, immunoglobulin E and peripheral blood e- osinophil count in predicting the progno＇sis of bronchiolitis. Method To detect LTE4, IgE and EC of 62 patients in the acute stage and convalescence, and 30 cases in the control group. 62 patients were divided into observation group and control group randomly, and the observation group were treated with Montelukast. Three months after dis- charge,the number of cases with wheeze outbreak was observed. Result LTE4 and IgE of observation group were synchronous significantly increased in the acute stage and convalescence compared with control group （P〈0.01）. There was no significant difference of EC between two groups（P〈0.05）. The recurrence of observation group rate was lower significantly than that of control group. Conclusions LTE4 and IgE were important inflammatory media- tors in pathogenic process of capillary bronchitis and EC could not complete represent the airway inflammation. Oral Montelukast have effects in the early intervention,and can decrease morbidity of capillary bronchitis.