沙利度胺治疗银屑病的疗效及影响因素COX分析

Analysis of effect and influence factors of Thalidomide in treatment of psoriasis

目的探讨沙利度胺治疗银屑病并对其疗效进行评价，同时分析影响疗效的其他相关因素。方法97例患者随机分成两组，实验组（沙利度胺，THD）；对照组（甲氨蝶呤．MTX）。治疗12周，采用Log-rank检验比较两组之间的疗效情况．Cox比例风险模型评价与疗效有关的因素。结果两组患者的中位好转时间分别是15d和21d。差异有统计学意义，沙利度胺组起效快；Cox回归模型分析显示：治疗方式、民族、治疗前的IL-2水平及治疗前的CD4＋T细胞是银屑病患者疗效的主要影响因素。结论沙利度胺比甲氨蝶呤治疗银屑病起效快．疗效好，不良反应少。

Objective To evaluate the efficacy of Thalidomide in treatment of psoriasis, also to investigate the COX re- gression model analysis of factors influencing Thalidomide in the treatment of psoriasis. Methods 97 patients with psoriasis were separated randomly into two groups who were treated 12 weeks with Thalidomide groups（experimen- tal group） or with MTX（methotrexate） group（control group）. We compared the curative efficacy of the two groups with the Log-rank test and COX Analysis of factors influencing Thalidomide in the treatment of psoriasis. Results The median time（the patient take a turn for the better with the treatment） of the two group：the experimental group was for 15 days,but the control group was for 21 days. The experimental group was significantly decreaseed com- pared to control group, thalidomide treated psoriasis was better than MTX. COX Analysis also demonstrated： The treatment,race,the compliance of the patients（oral drugs on time,to persist in the treatment） ,the expression level of IL-2 and CD4＋T cell were the independent factors. Conclusion Thalidomide treated psoriasis is better than MTX, poison the side effect be less.