摘要
目的探讨E-eadherin、CD44V6和HIF．1d在结肠癌组织中的表达及意义。方法应用免疫组织化学SP法检测90例结肠癌及癌旁正常结肠组织中E-eadherin、CD44V6和HIF-1α的表达。结果（1）E-eadherin在结肠癌中的高表达率为58．89％，低于在癌旁正常结肠组织中的高表达率90．00％（P〈0．05），CD44V6在结肠癌中表达阳性率为57．78％，高于在癌旁正常结肠组织中的表达阳性率5．56％（P〈0．05），HIF-1α在结肠癌中表达阳性率为61．11％，高于在癌旁正常结肠组织中的表达阳性率6．67％（P〈0．05）。（2）E-cadherin、CD44V6和HIF-1口的表达均与结肠癌有无淋巴结转移及结肠癌的Dukes分期有关（P〈0．05）。E-eadherin的表达还与结肠癌的分化程度有关（P〈0．05）。（3）结肠癌中CD44V6与E-cadherin的表达呈负相关（P〈0．05）。结论E-cadherin、CD44V6和HW-1α与结肠癌的发生、发展有关，并且在结肠癌的侵袭和转移中起重要作用，可作为判断结肠癌预后的重要指标。
Objective To investigate the expression and clinical significance of E-eadherin. CD44V6 and HIF-la in colorectal cancer. Methods The expression of E-cadherin,CD44V6 and HIF-1α were detected by immunohistochemi- cal staining（ streptavidine-peroxidase method） in 90 cases of colorectal carcinoma and 90 cases of adjacent normal colorectal mucosa. Results （1）The expression rate of E-cadherin in colorectal carcinoma was significantly lower than that in adjacent normal colorectal mucosa（58.89% Vs 90.00% ,P〈0.05）. The expression rate of CD44V6 in colorectal carcinoma was significantly higher than that in adjacent normal eolorectal mucosa（ 57.78%Vs 5.56 %, P 〈0.05）. The expression rate of HIF-1α in colorectal carcinoma was significantly higher than that in adjacent normal colorectal mucosa（ 61.11% Vs 6.67 %, P〈0.05）. （2）The expression of E-eadherin,CD44V6 and HIF-1α was asso- ciated with lymph node metastasis and Dukes stages（P〈0.05 ）. E-cadherin expression was associated with cell dif- ferentiation（P〈0.05）. （3）The expressions of CD44V6 and E-cadherin were negative related in the colorectal cancer （P〈0.05）. Conclusion E-cadherin,CD44V6 and HW-1α are associated with the tumorigenesis and development of the colorectal cancer,and play an important role in invasion and metastasis of the colorectal cancer. Detection of the expression of E-cadherin,CD44V6 and HIF-1α in the colorectal cancer may serve as important prognostic predictors.
出处
《中国误诊学杂志》
CAS
2012年第18期4866-4868,共3页
Chinese Journal of Misdiagnostics
