肿瘤标志物的联合检测在肺癌诊断中的临床价值

Diagnostic value of combined detection of serum tumor markers in patients with lung cancer

目的探讨血清中CEA、CA125、NSE和CYFRA21-1四种肿瘤标志物联合检测在不同组织类型肺癌中的临床诊断价值。方法采用电化学发光免疫分析技术测定116例肺癌患者及65例健康人血清中的CEA、CA125、NSE利CYFRA21-1水平。结果CYFRA21-1、NSE、CEA、CA125四项肿瘤标志物肺癌组检测水平均显著高于对照组（P〈0．01），肿瘤标志物测定水平与病理组织类型有关。其中CYFRA21-1在鳞癌及腺癌的阳性率分别为73．21％、63．64％；NSE在小细胞肺癌的阳性率为62．50％；CEA和CA125检测的阳性率及血清水平以腺癌最高；四项联合检测的阳性率为82．76％。结论血清CEA、CA125、NSE和CYFRA21-1的联合检测有助于提高肺癌的诊断效率，并对组织分型有较高的参考价值。

Objective To investigate the clinical value of combined measurement of serum CEA, CA125, NSE, CY- FRA21-1 for the diagnosis of lung cancer. Methods One hundred and sixteen patients with lung cancer confirmed histologically were studied. The levels of CEA, CA125 CYFRA21-1, NSE were assayed and compared between the lung cancer group（ 116 cases） and healthy control group（65 cases） by electrochemiluminesence immunoassay. Results The levels of CYFRA21-1, NSE,CEA, and CA125 in the lung cancer group were significantly higher than those in the control group（P〈0.01）. The levels of serum CEA,CA125, CYFRA 21-1 and NSE were related to types of pa- thology. The highest positive rates of CYFRA 21-1 for squamous cell carcinoma were 73.21% and 63.64% for ade- nocarcinoma;Tbe positivity of NSE for small cell lung cancer （SCLC） was 62.50% ;The higher levels and positivity of CEA and CA125 appeared in adenocareinoma. Their combined detection could markedly improve the positivity for lung cancer detection （82.76%）. Conclusion CEA,CA125 ,CYFRA21-1 and NSE are useful for the diagnosis of the lung cancer and histological type, especially combining detection of the four serum tumor markers .