摘要
目的探讨紫苏油对二甲基苯蒽（DMBA）诱导的大鼠乳腺癌的化学预防作用。方法将Wistar大鼠随机分为A组（肿瘤对照组），B组（诱导前应用紫苏油），C组（诱导后应用紫苏油）。一次性皮下给予DMBA诱导大鼠乳腺癌模型发生，观察紫苏油对DMBA诱导的乳腺癌模型大鼠的肿瘤发生部位、发生时间、肿瘤直径、荷瘤数量、大鼠生长情况的影响。结果紫苏油能明显抑制大鼠乳腺癌的发生，推迟大鼠乳腺癌的发生时间，降低肿瘤发生率。结论紫苏油对DMBA诱发的大鼠乳腺癌有预防作用，其机制可能为：紫苏油中的有效成分a-亚麻酸增强荷瘤大鼠免疫系统的抵抗力，清除血中氧化应激产生的氧自由基，抑制肿瘤细胞的增殖。
Objective To discuss the prevention role of Perilla oil in rats with breast cancer induced by dimethyl benzene anthracene. Methods Wistar rats were randomly divided into group A（control group）, tumor group B（ induc- tion application Perilla oil}, before the group C（ after induction application PeriUa oil ）. One-time subcutaneous gived DMBA rats induced by breast cancer happen, observation model of induction of DMBA Perilla oil rat models of breast cancer tumor location and time of occurrence, tumor diameter, tumor-burdened quantity, rat growth situation. Results Perilla oil significantly suppressed rat breast cancer, delayed rat breast cancer incidence tumors, reduce time. Con- elusion Perilla to DMBA oil induced rat breast cancer prevention role,its mechanism may for the effective ingredi- ent：basil oil a-linolenic acid enhance immune system rats tumor-burdened resistance, remove blood from the oxidative stress oxygen free radicals,inhibiting tumor cell proliferation.
出处
《中国误诊学杂志》
CAS
2012年第18期4878-4880,共3页
Chinese Journal of Misdiagnostics
基金
自然科学基金资助项目,陕西省延安市科技计划项目（2009KS-06）
