期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血清IL-8和CRP水平变化对新生儿细菌感染的意义 被引量：2

原文传递
导出
摘要 目的探讨血清IL-8和CRP水平变化对新生儿细菌感染的意义。方法采用ELISA法测定临床感染组、可疑感染组和对照组血清IL-8和CRP水平。结果临床感染组、可疑感染组治疗前IL-8、CRP水平与对照组相比，差异显著，临床感染组显著高于可疑感染组和对照组，可疑感染组显著高于对照组；临床感染组、可疑感染组治疗前IL-8、CRP水平显著高于治疗后。临床感染组、可疑感染组有效治疗后IL-8、CRP水平与对照组相比，差异无统计学意义。结论新生儿细菌感染时血清IL-8、CRP显著升高，能够反映疾病的严重程度及评价疗效，可作为新生儿细菌感染的早期诊断指标。
作者 刘春红
机构地区 河南省周口市妇幼保健院儿科
出处 《中国误诊学杂志》 CAS 2012年第18期4947-4948,共2页 Chinese Journal of Misdiagnostics
关键词 细菌感染/诊断 C反应蛋白质/分析 白细胞介素8/分析
分类号 R722.130.4 [医药卫生—儿科]
  • 相关文献

参考文献10

  • 1Bender L, Thaarup J, Varming K,et al. Early and late markers for the detection of early-onset neonatal sepsis[J]. Dan Med Bull, 2008,55(4) :219-23.
  • 2Kurt AN, Aygun AD, Godekmerdan A, et al. Serum IL-lbeta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis [J].Mediators Inflamm, 2007, 2007: 31397.
  • 3Koeabas E, Sarikcioglu A, Aksaray N,et al. Role of procalcito- nin, C-reactive protein, interleukin-6, interleukin-8 and tumor necrosis factor-a in the diagnosis of neonatal sepsis[J]. Turk J Pediatr,2007,49(1) : 7-20.
  • 4陈翠芳,吴新梅,李开为,邱国新,赵才祥.新生儿细菌感染血乳铁蛋白、IL-6与IL-8的测定及临床意义[J].华中医学杂志,2009,33(2):90-91. 被引量：6
  • 5吴尤佳,徐美玉.IαIP、IL-8在新生儿细菌感染早期诊断中的意义[J].江苏医药,2009,35(11):1290-1292. 被引量：4
  • 6McWilliam S, Riordan A. How to use: C-reactive protein[J]. Arch Dis Child Educ Pract Ed,2010,95(2):55-58.
  • 7Mannan MA, Shahidullah M, Noor MK, et al. Utility of C-reactive protein and hematological parameters in the detection of neonatal sepsis[J]. Mymensingh Med J,2010,19(2):259-263.
  • 8Chen HL, Hung CH, Tseng HI, et al. Circulating chemokine levels in febrile infants with serious bacterial infections [J]. Kaohsiung J Med Sci,2009,25(12) ..633-639.
  • 9Cetinkaya M, Ozkan H, Koksal N, et al. Comparison of serum amyloid A concentrations with those of C-reactive protein and procalcitonin in diagnosis and follow-up of neonatal sepsis in premature infants [J]. J Perinatol, 2009,29(3) :225-231.
  • 10Beceiro Mosquera J, Sivera Monzo CL, Oria de Rueda Salguero O, et al. Usefulness of a rapid serum interleukin-6 test combined with C-reactive protein to predict sepsis in newborns with suspicion of infection[J]. An Pediatr (Barc) ,2009,71(6) :483-488.

二级参考文献12

  • 1FAde L, Hipolito RB, Hwang FF, et al. Lactoferrin protects neonatal rats from gut-related systemic infec- tion. Am J Physiol Gastrointest Liver Physiol, 2001, 281(5) :G1140-1150.
  • 2Haversen L, Ohlsson BG, Hahn-Zoric M, et al. Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B. Cell Immunol, 2002, 220 (2) :83-95.
  • 3Elass E, Masson M, Mazurier J, et al. Lactoferrin inhibits the tipopolysaccharide-Induced expression and porteoglycan-binding abiilty of interleukin-8 in human endothelial cells. Infect Immun, 2002, 70 (4) : 1860- 1866.
  • 4Kurt AN, Aygun AD, Godekmerdan A, et al. Serum IL-1 beta, IL-6, IL-8, and TNF-alpha levels in early diagnosis and management of neonatal sepsis. Mediators Inflamm, 2007, 2007: 31397.
  • 5Kocabas E, Sarikcioqlu A, Aksaray N, et al. Role of procalcitonin, C-reactive protein, interleukin-6, interleukin-8 and tumor necrosis factor-alpha in the diagnosis of neonatal sepsis. Turk J Pediatr, 2007, 49(1) :7- 20.
  • 6Opal SM, Lim YP, Siryaporn E, et al. Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis[J]. Crit Care Med, 2007,35 (2) : 387 392.
  • 7Zhou L, Hascall VC, Kimata K. Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex[J]. J Bio Chem, 2004,279 (37) : 38079-38082.
  • 8Beak YW, Brokat S, Padbuty JF, et al. Inter-alpha inhibitor proteins in infants and decreased levels in neonatal sepsis[J]. J Pediatr,2003,143(1) : 11 15.
  • 9Orlikowsky TW, Neunhoeffer F, Goclz R, et al. Evaluation of IL-8-coneentrations in plasma and lysed EDTA-blood in healthy neonates and those with suspected early onset bacterial infection[J]. Pediatr Res,2004,56(5):804-809.
  • 10李耿,伍佰祥.新生儿细菌感染标记物的研究进展[J].中华儿科杂志,2007,45(9):674-678. 被引量：12

共引文献7

同被引文献15

引证文献2

二级引证文献10

中国误诊学杂志
2012年 第18期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部