不同剂型、剂量的肾上腺皮质激素治疗小儿特发性血小板减少性紫癜疗效观察

TREATMENT ITP WITH ADRENOSTERONE IN DIFFERENT FORMS AND DOSAGES

三种不同剂型、剂量的肾上腺皮质激素治疗小儿特发性血小板减少性紫癜 ,结果表明 :对出血症状的控制速度 ,地塞米松冲击组优于甲基强的松龙冲击组 ,也优于强的松组 ;血小板计数的升高幅度也是冲击组优于常规剂量组 ,差异有显著意义 ;治疗后 PAIg G的下降在冲击治疗组优于常规剂量组。建议 :对于急性出血症状明显、且 PAIg G增高也较明显的患儿 ,应首选大剂量糖皮质激冲击治疗。

We treat ITP with adrenoterone in three different forms and dosages (large dosage dexamethason, large dosage methylprednisone and routine prednison). The result show that A: dexamethason in large dosage is better than methylprednison than prednison in controlling bleeding. B: The large dosage groups is better than routine group in increasing platelet count (P<0.05), but there is no difference between two large dosage groups. C: The large dosage groups is better than routine group in decreasing PAIgG. We suggest that the large dosage adrenosterone should be selected in the patients with the acute、serious bleeding and high level of PAIgG