血清心肌肌钙蛋白Ⅰ测定在心肌梗死中的应用

The assay of serum cardiac troponin I for diagnosing acute myocardial infarction

目的 为探讨血清心肌肌钙蛋白Ⅰ测定在心肌梗死中的诊断价值。方法 采用磁微粒子化学发光技术定量检测急性心肌梗死 (AMI)患者、正常人血清心肌肌钙蛋白Ⅰ (cTnI) ,并与肌酸激酶同工酶 (CK -MB)活性比较。结果 cTnI对AMI患者敏感性为 98.4% ,阳性率在发病后 4小时内达 44 .4% ,7天阳性率仍达 38.4%。结论 其阳性出现时间早持续时间长 ,cTnI灵敏度及特异性明显优于CK -MB活性 ,是高度灵敏。

Objectives To compare the clinical diagnostic value of serum cardiac troponin(cTnI) with creatine kinase MB(CK-MB) in different stage of acute myocardial infarction(AMI).Methods Serum cTnI was quantified by Chemiluminesces Immunoassay (CLIA) between the AMIs and the normals,and compared its activity with CK-MB′S.Results The sensitivity of cTnI for diagnosis of AMI was 98.4%.The positive rate reached 44.4% on 4 hour,and 38.45% on seven days in patientos with AMI.Conclusions cTnI appeared positive early and exist long in serum.The senstive and specificity of cTnI was obviously superior to CK-MB′s activity.So cTnI was a more sensitive and specific serum marker in acute myocardial infarction