用射出精子、附睾精子、睾丸精子显微授精治疗男性不育

Intracytoplasmic injection with sperm from ejaculation, epididymis and testitis in treating different male infertility with oligoasthenozoospermia or azospermia

目的 回顾分析 3种不同来源精子显微授精治疗男性不育 40 0个周期。 方法 分别用射出精子、附睾精子或睾丸精子注射行卵胞浆内单精子辅助授精 (ICSI)治疗各种男性少弱畸形精子症及无精子症不育患者。 结果 射出精子组 2 77个治疗周期 ,授精率 6 9 6 % ,临床妊娠率2 8 9%。附睾精子组 10 4个ICSI周期 ,授精率 6 5 9% ,临床妊娠率 37 5 %。睾丸精子组 19个ICSI周期 ,授精率 6 5 7% ,临床妊娠率 2 1 1%。 3组结果比较 ,差异无显著性意义。 结论 ICSI可以治疗各种因素的男性不育 ,除非精子活动率为 0时其结果不授精液常规参数影响 。

Objective To retrospectively study 400 intracytoplasmic sperm injection (ICSI) cycles by using three different sources of sperm. Method Different male infertility with oligoasthenozoospermia or azospermia was treated by ICSI using sperm from ejaculation, epididymis and testitis. Results In the ejaculation group( n =277),the fertilization rate was 69 6% and the clinical pregnancy rate 28 9%. In the 104 cycles using epididymal sperm, the fertilization and clinical pregnancy rate was 65 9% and 37 5% respectively. And the fertilization and clinical pregnancy of testitis sperm ( n =19) was 65 7% and 21 1%. The difference of fertilization and clinical pregnancy rate among the three groups were not significant.come has nothing to do with the common parameters of semen except that the sperm motility is 0, but the effectiveness of ICSI should be studied by long term observation.