多西他赛联合奈达铂治疗晚期非小细胞肺癌疗效观察

The observation of the effecf of docetaxel combination with nedaplatin in the treatment of patients with advanced stage of nonsmall-cell lung cancer

目的 观察多西他赛联合奈达铂在晚期非小细胞肺癌治疗中的疗效。方法 晚期非小细胞肺癌患者共72例,随机分两组。观察组采用多西他赛联合奈达铂的化疗方案,对照组采用多西他赛联合顺铂的化疗方案。观察两组化疗前后疗效、无进展时间、总生存时间以及毒副反应等。结果 观察组患者CR率8.3%、PR率38.9%、总缓解率47.2%,与对照组患者的CR率5.6%,PR率36.1%以及总缓解率（CR＋PR）41.7%,差异均无统计学意义（P〉0.05）。两组患者无进展生存时间与总生存时间差异均无统计学意义（均P〉0.05）。观察组消化道反应的发生率均显著低于对照组。结论 多西他赛联合奈达铂是治疗晚期非小细胞肺癌有效的方法之一,其毒性反应小,患者易于耐受。

Objective To observe the effect of docetaxel combination with nedaplatin in the treatment of patients with advanced stage of nonsmall-cell lung cancer.Methods 72 patients with advanced stage of nonsmall-cell lung cancer were collected and randomly divided into observation group and control group.Docetaxel combination with nedaplatin was used in observation group and docetaxel combination with cisplatin was used in control group.The curative effect,no advancement time,total live time and adverse reaction were observed in each group.Results The CR rate 8.3%,PR rate 38.9%,total remission rate 47.2%in observation group had no significant difference with control group.There was no significant difference in no advancement time and total live time between these two groups.The rate of digestive reactions was significantly lower in observation group than in control group（all P〈0.05）.Conclusion Docetaxel combination with nedaplatin was an effective method in the treatment of advanced stage of nonsmall-cell lung cancer.The toxic reaction was low and easily to tolerte.