摘要
目的观察白花丹醌对白血病异种移植瘤的体内作用。方法用NB4细胞构建白血病小鼠模型,白花丹醌组(2mg/(kg.d)),亚砷酸组(4mg/(kg.d)),分别腹腔给药15d,计算抑瘤率,凋亡指数(AI)并进行病理组织学检查。结果白花丹醌组抑瘤率为40.49%(P<0.01),AI为(8.52±1.49)%(P<0.01),未出现明显的病理组织损伤。亚砷酸组则无明显的抑瘤作用,凋亡作用不明显(P>0.05),部分伴有心肌组织的损伤。结论 :白花丹醌具有抑制肿瘤生长,诱导凋亡的作用,可能成为白血病治疗的新选择。
OBJECTIVE To observe the effect of Plumbagin in vivo using xenografts mice. METHODS The leukemia mouse model was developed with implantation of NIM cell;plumbagin group （2mg/（kg· d）） and arsenic trioxide group （4mg/（kg· d）） were treated for 15 days by i. p route;suppression of tumor growth and the apop- totic index （AI） were calculated. The histopathologic change was detected. RESUTLS The inhibition rates of plumbagin group was 40.49 % （P 〈 0.01 ）, AI was（8.52 ±1.49） % （P 〈 0.01 ）, and without any obvious patholo- gy of tissue damage.There was no significant effect in arsenic trioxide group except some tissue damage in heart. CONCLUSION Plumbagin may inhibit tumour growth and induce apoptosis, can be a new choice for leubemia treatment.
出处
《海峡药学》
2012年第6期14-16,F0004,共4页
Strait Pharmaceutical Journal
