小胶质细胞与帕金森病(英文)

Microglia and Parkinson's disease

背景:由于多巴胺能神经元对氧化应激特别敏感,小胶质细胞的重要特点之一是易活化,而活化的小胶质细胞是氧自由基产生的主要来源,因此小胶质细胞的激活在帕金森病的发病和病情进展中具有更加重要的作用。目的:总结讨论小胶质细胞与帕金森病的相互关系。方法:由第一作者用计算机检索中国期刊全文数据库(CNKI:2000/2010)和Medline数据库(2000/2010),检索词分别为"帕金森病,小胶质细胞"和"Parkinson’sdisease,Microglia",从小胶质细胞激活后产生的细胞因子、毒性物质对帕金森病发病的影响与抑制小胶质细胞的激活,阻止神经毒性因子的损害作用进而阻止帕金森病的进展2方面进行总结,对小胶质细胞与帕金森病的相互关系作相关介绍。结果与结论:共检索到112篇文章,按纳入和排除标准对文献进行筛选,共纳入27篇文章。结果表明小胶质细胞的激活会损伤多巴胺能神经元,从而引发帕金森病。而帕金森病的发生发展则使多巴胺递质进一步减少、继续损伤多巴胺能神经元并释放炎性因子促使小胶质细胞激活。抑制小胶质细胞的激活则有可能阻止帕金森病的进展。

BACKGROUND： Because dopaminergic neurons are particularly sensitive to oxidative stress, microglia is characteristics of being prone to activation, and activated microglia is the main source of oxygen free radical production, so microglia activation is more important in the pathogenesis of Parkinson＇s disease and illness progress.OBJECTIVE： To summarize the correlation between microglia and Parkinson＇s disease.METHODS： An online computer-based retrieval was performed by the first author among the Chinese Journal Full-Text Database （CNKI： 2000/2010） and Medline （2000/2010） Database, with key words of ＂Parkinson＇s disease, microglia＂ in English and Chinese. The correlation between microglia and Parkinson＇s disease was discussed through two aspects, one is the influence of cell factors and toxic substance produced after microglia activation on Parkinson＇s disease, the other is the inhibition of microglia and prevention of nerve toxic factors on Parkinson＇s disease progress.RESULTS AND CONCLUSION： A total of 112 articles were screened out according to inclusion and exclusion criteria, and 27 of them were involved in the analysis. Results showed that microglia activation will damage dopaminergic neurons, and cause Parkinson＇s disease. And the occurrence and development of Parkinson＇s disease may further reduce the neurotransmitter dopamine, continue to damage dopaminergic neurons and release the inflammatory factor, thus promoting microglia activation. Inhibition of microglia activation is likely to stop the progress of Parkinson＇s disease.