肾上腺髓质素前体N端20肽在血压调节中的作用

The role of proadrenomedullin N terminal 20 peptide in the regulation of blood pressure

目的 探讨肾上腺髓质素前体N端 2 0肽 (PAMP)的心血管效应以及原发性高血压(EH)患者血浆PAMP的浓度变化。方法 静注PAMP ,观察其对大鼠的血压、心率、左室收缩峰压及舒张血管平滑肌的作用。用放免法测定EH患者的血浆PAMP浓度。结果 PAMP可以降低大鼠血压和舒张大鼠主动脉环张力 ,并呈剂量依赖性 ;EH患者血浆PAMP含量〔(30 .6 0± 2 .2 6 )ng/L〕明显高于对照组〔(18.41± 2 .33)ng/L ,P <0 .0 1〕 ,随病期的加重升高更明显 (P均 <0 .0 1) ,与平均动脉压呈正相关 (r=0 .431,P <0 .0 5 )。结论 PAMP是一种舒血管肽 ;

Objective To elucidate the effect of proadrenomedullin N terminal 20 peptide (PAMP) in cardiovascular system and clinical significance of PAMP plasma concentration in the patients with essential hypertension (EH). Methods The blood pressure, heart rate, left ventricular peak systolic pressure and the relaxation of vascular smooth muscle of the rats were observed by intravenous administration of PAMP. The plasmaconcentrationofPAMPinEH patients was measured by radioimmunoassay. Results PAMP reduced the blood pressure and the tension of aorta ring in a dose dependent manner in rats. The plasma concentration of PAMP was significantly higher in EH patients than that in control group 〔(30.60±2.26)ng/L vs (18.41±2.33)ng/L,P<0.01〕, and had a positive correlation with the mean arterial pressure (r=0.431,P<0.05). It was significantly elevated with the disease advanced (P<0.01). Conclusion PAMP is a vasodilator peptide, the change of PAMP appears a compensatory mechanism to maintain homeostasis in EH patient.