榄香烯透皮凝胶的制备及体外透皮性能

Preparation of elemene transdermal gel and its skin penetration in vitro

背景:选择合适的载体材料对药物透皮性能的影响是制备榄香烯透皮制剂首先要解决的问题。目的:建立一种榄香烯透皮凝胶并观察其体外透皮性能。方法:采用具有良好生物相容性的亲水性高分子材料聚乙烯醇和羧甲基纤维素钠制备榄香烯透皮制剂。在体外透皮实验装置上,用鼠背皮肤为屏障进行经皮渗透实验,高效气相色谱检测榄香烯的经皮渗透量。结果与结论:聚乙烯醇和羧甲基纤维素钠的使用比例对榄香烯的透皮能力没有显著影响;两种高分子骨架材料在凝胶基质中的浓度对榄香烯透皮能力有一定的影响,以30%含量(聚乙烯醇与羧甲基纤维素钠总量)为最佳。提示此种透皮凝胶可用作榄香烯的良好载体。

BACKGROUND： Effect of choosing a suitable carrier material on elemene transdermal properties is the problem of elemene transdermal preparation and need to be resolved first. OBJECTIVE： To prepare an elemene transdermal gel and to investigate its skin penetration in vitro METHODS： An elemene transdermal gel was prepared by using hydrophilic polymer polyvinyl alcohol and sodium carboxymethyl cellulose each with good biocompatibility. In the experimental installation for skin penetration in vitro, the mouse dorsal skin was isolated as a barrier for percutaneous penetration experiments. Percutaneous infiltration quantity of elemene was detected by high resolution gas chromatography. RESULTS AND CONCLUSION： The ratio of polyvinyl alcohol and scarboxymethyl cellulose showed no significant effect on the transdermal ability of elemene. But their concentration in the gel matrix had a certain influence on the transdermal ability of elemene, and 30% content （total content of polyvinyl alcohol and sodium carboxymethyl cellulose） was optimal. These findings suggest that this kind of transdermal gel can be used as a good carrier for elemene.