VEGF、KDR在卵巢上皮性肿瘤组织中的表达及其与血管新生的关系

Expression of VEGF and KDR in epithelial ovarian tumor tissue and its relationship with microvascular density

目的:探讨VEGF、KDR在卵巢上皮性肿瘤组织中的表达及其与微血管密度的关系。方法:用免疫组化技术检测卵巢上皮性肿瘤组织中VEGF、KDR的表达并测定IOD值,在光镜下计数MVD。结果:VEGF和KDR的表达在卵巢良恶性肿瘤组织中有显著性差异。VEGF表达阳性的MVD值显著高于VEGF表达阴性者(P<0.01);MVD与VEGF、KDR表达呈正相关(〈P0.05),VEGF表达与KDR表达呈正相关(P〈0.01)结论:VEGF、KDR和MVD均能反映卵巢上皮性肿瘤的良恶性和恶性进展程度,可作为衡量卵巢肿瘤良恶性及判断预后的重要参考指标。

Objective：To study the expression of VEGF and its receptor KDR in epithelial ovarian tumor tissue and the relationship between them and MVD）. Methods： Expression of VEGF. KDR and were examined by immunohistochemical technique in epithelial ovarian tumor tissue. The integral optical density （IOD） was measured. MVD was counted by light microscope. Results：The positive rate and IOD of VEGF and KDR expression were increased in sequence of the comparion cases, benign cases and malignant cases,and there were significant differences among them（ P 〈 0.01 ）; The average MVD was higher in the malignant cases with positive expression of VEGF than those without expression of VEGF （ P 〈 0.01 ）; MVD was significantly correlated with the expression of VEGF and KDR（ P 〈 0.05 ）. The expression of VEGF was significantly correlated with the expression of KDR. （ P 〈 0.01 ）. Conclusion：Quantification of VEGF, KDR and MVD in epithelial ovarian tumor may provide valuable markers for estimating the prognosis of the ovarian epithelial tumors.