HLA-B27检测在强直性脊柱炎中的临床应用

目的:探讨HLA-B27抗原检测在强直性脊柱炎(AS)早期诊断中的临床价值。方法:使用流式细胞技术对30例健康体检者、41例AS疑似患者和52名AS患者进行HLA-B27抗原检测。结果:体检对照组、AS疑似组和AS组的HLA-B27阳性率分别为0%、12.2%和90.4%,AS组、AS疑似组的HLA-B27阳性率明显高于体检对照组(P<0.01),AS组的HLA-B27阳性率明显高于AS疑似组(P<0.01)。结论:HLA-B27抗原与AS疾病相关,检测HLA-B27抗原对疑似AS患者的早期诊断有重要意义。

Objective： Discuss the clinical application value of HLA-B27 antigen test in the early diagnosis of ankylosing spondyli- tis （AS）. Method： Use flow cytometry to conduct HLA-B27 antigen test for 30 physical examination testees, 41 suspected AS pa- tients and 52 AS patients. Result.. The positive rates of physical examination control group, suspected AS group and AS group are 0%, 12.2% and 90. 4% respectively. The HLA-B27 positive rates of AS group and suspected AS group are evidently higher than that of physical examination group （P〈0.01） while the HLA-B27 positive rate of AS group is evidently higher than that of suspec- ted AS group （P〈0. 01）. Conclusion： HLA-B27 antigen is related to AS disease. HLA-B27 antigen test has important significance for the early diagnosis of suspected AS patients.