Slug和E-cadherin在结直肠癌组织中的表达及临床意义

Expression and significance of Slug and E-cadherin in colorectal carcinoma

目的探讨Slug和E-cadherin在结直肠癌组织中的表达及预后意义。方法应用免疫组化SP法检测65例结直肠癌组织,25例癌旁正常结直肠组织中Slug和E-cadherin的表达,分析两者表达水平与临床病理特征及患者预后的关系。结果 Slug在结直肠癌组织中异常表达率为47.1%,而在正常结直肠组织中表达率为12%,差异有统计学意义(P<0.01);E-cadherin在结直肠癌组织中异常表达率为55.4%,而在正常结直肠组织中表达率为8%,差异有统计学意义(P<0.01);两者阳性表达率与肿瘤浸润深度、分化程度、淋巴结转移、Dukes分期相关性均有统计学意义(P<0.05)。Slug、E-cadherin、淋巴结转移、Dukes分期可成为影响结直肠癌预后的独立因素(P<0.05)。结论 Slug和E-cadherin的表达异常可能与结直肠癌的发生发展、转移相关并可作为评价结直肠癌生物学行为和预后的重要指标。

Objective To explore the expression and the prognostic significance of Slug and E-cadherin in colorectal carcinoma tissues. Methods Expressions of Slug and E-cadherin in 65 colorectal carcinoma tissues and 20 normal colorectal tissues were detected by SP immunohistochemistry. Relationship between the expressions level of Slug and E-cadherin and the clinical pathological features and the prog- nosis of patients were analyzed. Results Abnormalities expression rate of Slug in colorectal cancer tissues was 47.1%, while in normal colorectal tissues the expression rate was 12%. There was significant difference between two groups （ P 〈 0. 01 ）. Abnormalities expression rate of E-cadherin in colorectal cancer tissues was 55.4%, while in normal colorectal tissues the expression rate was 8%. There was significant difference between two groups （P 〈 0.01 ）. Both Slug and E-cadherin positive expression were correlated with tumor infiltration depth, differentiation, lymph node metastasis, Dukes stages （ P 〈 0. 05 ）. Slug expression was not correlated with E-cadherin expression. Expressions of Slug and E-cadherin, lymph node metastasis and Dukes stages were an independent prognostic factor （ P 〈 0. 05 ）. Conclusions Expression of Slug and E-cadherin may correlate with occurrence, development and metastasis of colorectal carcinoma. The expression of Slug and E-cadherin can be regarded as valuable indicators for evaluating biological behavior and the prognosis of colorectal carcinoma.