期刊文献+

利多卡因对兔离体气管平滑肌张力的影响

下载PDF
导出
摘要 目的观察利多卡因对兔离体气管平滑肌张力的影响。方法利用兔离体气管平滑肌制作36条气管平滑肌,随机分为6组,记录初始值及1、5、10、15、20 min六个时间点的张力值。结果 3×10-5 mol/L利多卡因对兔离体气管平滑肌张力无明显影响,对乙酰胆碱(Ach)诱发的兔离体气管平滑肌痉挛有松弛作用,对组胺诱发的兔离体气管平滑肌张力的升高无明显影响。结论利多卡因对兔离体气管平滑肌的张力没有明显影响,对Ach诱发的兔气管平滑肌张力升高有抑制作用,对组胺诱发的张力升高无明显影响。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第13期2784-2786,共3页 Chinese Journal of Gerontology
  • 相关文献

参考文献10

  • 1Groeben H,Schwalen A,Irsfeld S. Intravenous lidocaine and bupivacaine dose-dependently attenuate bronchial hyperreactivity in awake volunteers[J].Anesthesiology,1996,(03):533-539.doi:10.1097/00000542-199603000-00007.
  • 2Hirota K,Hashimoto Y,Sato T,er al. Bronchoconstrictive and relaxant effects of lidocaine on the airway in dogs[J].Critical Care Medicine,2001,(05):1040-1044.doi:10.1097/00003246-200105000-00034.
  • 3林耀广.现代哮喘病学[M]北京:中国协和医科大学出版社,2004281-283.
  • 4Groben H,Peters J. Lidocaine exerts its effect on induced bronchospasm by mitigating reflexes,rather than by attenuation of smooth muscle contraction[J].Acta Anaesthesiologica Scandinavica,2007,(03):359-364.doi:10.1134/S1990793111020382.
  • 5Kai T,Nishimura J,Kobayashi S. Effects of lidocaine on intracellular Ca2 + and tension in airway smooth muscle[J].Anesthesiology,1993,(05):954-965.doi:10.1097/00000542-199305000-00021.
  • 6Starobin D. Efficacy of Local Versus Intravenous Lidocaine for Cough Suppression During Flexible Bronchoscopy[J].Journal of Bronchology,2002,(03):182-185.doi:10.1097/00128594-200207000-00003.
  • 7Groeben H,Grosswendt T,Silvanus MT. Airway anesthesia alone does not explain attenuation of histamine-induced bronchospasm by local anesthetics:a comparison of lidocaine,ropivacaine,and dyclonine[J].Anesthesiology,2001,(03):423-428.doi:10.1097/00000542-200103000-00010.
  • 8闻大翔.肌松药与支气管痉挛[J].国外医学(麻醉学与复苏分册),2002,23(1):36-38. 被引量:3
  • 9Chang H,Togias A,Brown RH. The effects of systemic lidocaine on airway tone and pulmonary function in asthmatic subjects[J].Anesthesia and Analgesia,2007,(05):1109-1115.doi:10.1213/01.ane.0000260638.57139.87.
  • 10Burehes BR,Warner DO. Bronchospasm after intravenous lidocaine[J].Anesthesia and Analgesia,2008,(04):1260-1262.

二级参考文献21

  • 1Caulfield MP et al. Pharmacol Ther,1993;58:319
  • 2Mitchell RW et al. Am J Respir Cell Mol Biol,1991;5:56
  • 3Roffel AF et al. Br J Pharmacol, 1990; 99: 293
  • 4Hejnova L et al. Eur J Pharmacol,1995;291:427
  • 5Hou VY et al. Anesthesiology,1998;88:744
  • 6Okanlami OA et al. Anesthesiology, 1996;84:155
  • 7Simons FE et al. N Engl J Med,1994;330:1663
  • 8Naguib M et al. Br J Anaesth,1991;67:320
  • 9Doenicke A et al. Anesthesiology,1993;79:A931
  • 10Naguib M et al. Br J Anesthesia,1995;75:588

共引文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部