膜联蛋白Ⅱ的表达与前列腺癌临床病理特征及预后的关系

The correlations between the expression of annexin Ⅱ and clinicopathologic features as well as prognosis of prostate cancer

目的:研究膜联蛋白Ⅱ(annexinⅡ)表达与前列腺癌(PCa)临床病理特征及预后的关系。方法:采用免疫组织化学方法(SP法)检测annexinⅡ在40例前列腺增生症(BPH)和85例PCa标本中的表达情况,统计分析annexinⅡ表达与PCa临床病理特征及预后的关系。结果:annexinⅡ在PCa、BPH表达阳性率分别是62.4%、92.5%,两者差异有统计学意义(P<0.05),annexinⅡ在不同Gleason评分、前列腺特异性抗原(PSA)水平、临床分期、不同危险度PCa中,经统计学分析,它们在各组的差异均有统计学意义(P<0.05),Kaplan-Meier生存曲线分析发现annexinⅡ表达阴性PCa患者的生存率显著低于annexinⅡ表达阳性(P<0.01),预后分析发现annexinⅡ表达阴性性均预示着PCa预后较差(P<0.01)。结论:膜联蛋白Ⅱ表达与PCa的发生、进展及预后有关,可作为PCa诊断的分子标记物及预后判断的独立因子。

Objective：The aim of our work is to investigate the correlations between the expression of annexin U and Clinicopathologic features as well as prognosis of prostate cancer（PCa）. Method.. All prostate specimens were paraffin-embedded in paraffins and confirmed by the pathological diagnosis. They were divided into two groups：40 BPH,85 PCa. The 85 PCa were further divided into various groups according to Gleason＇s criterion, Prostate-specific antigen（PSA）, risk PCa,clinical stage. Expression of annexin Ⅱ was determined by immunohisto- chemical staining. The correlation among Expression of annexin Ⅱ and clinicopathologic features were analyzed by SPSS software. Result.. The results from immunohistochemical staining showed that the positive ratio of annexin Ⅱ expression were 62.4% in PCa,and 92.5 % in BPH. And there were significant difference between the expression of annexin Ⅱ and PCa as well as BPH（P〈0.05）. The 85 PCa were further divided into various groups according to Gleason, PSA, clinical stage, risk of PCa. And there were significant difference of the expression of annexin Ⅱ a- mong them（P〈0.05）. Kaplan-Meier survival curve showed that PCa patients with low or negative expression of annexin Ⅱ seem to have a poorly survival rate in comparison to those with positive and strong expression of annex- in Ⅱ. Prognosis analysis showed that PCa patients with low or negative expression of annexin Ⅱseem to have poorly prognosis,and annexin Ⅱ can serve as independent index of prognosis in PCa. Conclusion：Our study indicated that annexin Ⅱ play a key role in the development and progression of prostate cancer. It appeared to that the annexin Ⅱ could be used as the basis index of diagnosis and prognosis for PCa.