自身免疫相关性干眼动物模型的研究进展

Research advances in animal models of autoimmune related dry eye

干眼是最常见眼病之一,损伤眼表和视力,影响生活质量,其发病机制尚未完全明了,这严重限制了对干眼的有效治疗。值得关注的是,较为严重的干眼类型多见于自身免疫相关性干眼。近年来,随着转基因小鼠和敲除基因小鼠的出现及分子遗传学和免疫学等学科的飞速发展,人们已经成功建立了许多新的干眼动物模型,对自身免疫相关性干眼的研究有重大价值。

Dry eye is one of the most common eye diseases, which can affect the surface of eye ,vision acuity and the quality of life. However, the effective treatment of dry eye has limited seriously because its pathogenesis is not clear. Notably,the more se- rious dry eye types are the autoimmune related dry eye. In recent years,with the emer- sion of transgenic mice and gene knock-out mice, and the rapid development of molecu- lar genetics and immunology, many new animal models of dry eye have been estab- lished,which are significant to the study of autoimmune related dye eye.