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沙丁胺醇吸入对COPD患者腹腔镜手术期呼吸功能的影响 被引量:1

Effects of nebulized salbutamol of respiratory function in COPD patients undergoing laparoscopic operation
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摘要 目的观察沙丁胺醇吸入对慢性阻塞性肺通气功能障碍(COPD)患者腹腔镜手术期呼吸功能的影响。方法有轻-中度肺功能障碍的COPD患者50例,拟在全麻下行腹腔镜手术,随机均分为两组:A组麻醉前30min吸入沙丁胺醇气雾剂200μg;B组给予生理盐水喷雾剂作为对照。比较两组围麻醉期血气、气道压(Paw)和苏醒、拔管时间。结果 A组术中,尤其是气腹时的Paw、呼气末二氧化碳分压(PETCO2)、动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)及pH值变化均明显小于B组(P<0.05)。B组术中有5例出现气道痉挛,A组仅有1例。结论对COPD患者行腹腔镜术麻醉前予沙丁胺醇吸入,可有效降低气道痉挛发生率。 Objective To observe the effects of nebulized salbutamol of pulmonary function in chronie obstructive pulmonary disease (COPD) patients undergoing laparoscopic operation. Methods Fifty COPD patients of ASA Ⅱ-Ⅲ, without heart or endocrine disorders, undergoing selective laparoscopic operations under general anesthesia were randomly divided into two groups of A (25 cases, treated with salbutamol 200 μg spray at 30 min before anesthesia) and B(25 cases, treated with normal saline instead of salbutamol). Arterial blood gas analysis and airway pressure (Paw) were monitored perioperatively and the times of awakening and extubation were recorded. Results The changes of blood gas and Paw during operationespecially COs neumoabdomen, were less in group A than those in group B(P〈0. 05). Broncheal spasm during surgery occurred in 5 cases of group B, which was seen only in 1 case in group A. Conclusion The prophylactic salbutamol 200 g spray before operation can effeetively improve pulmonary function and reduce the occurrence of airway spasm and postoperative complications in COPE) patients undergoing laparoscopic surgery.
作者 孙鑫 宋杰
出处 《江苏医药》 CAS CSCD 北大核心 2012年第13期1565-1567,共3页 Jiangsu Medical Journal
关键词 沙丁胺醇 腹腔镜术 慢性阻塞性肺通气功能障碍 Salbutamol Laparoscopy Chronie obstructive pulmonary disease
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