摘要
目的:分析葛根素干预对运动训练大鼠血液流变学及运动能力的影响。方法:60只8周龄SD雄性大鼠,30只口服葛根素组和30只对照组,葛根素组再分为10只葛根素安静组,20只葛根素+训练组(10只为运动后即刻组,10只为运动后恢复24h组);同样30只对照组也分10只安静组,20只训练组(10只为运动后即刻组,10只为运动后恢复24h组),建立力竭游泳训练模型。通过灌服葛根素干预后,观测大鼠力竭游泳时间,测试各组大鼠全血黏度、血浆黏度、红细胞聚集指数、红细胞刚性指数、红细胞压积、红细胞沉降率(血沉)。结果:①安静时:与对照组相比,葛根素组大鼠全血黏度显著降低[(8.41±0.76),(6.51±0.92),P<0.05],红细胞刚性指数显著降低[(1.23±0.76),(0.98±0.72),P<0.05]和红细胞聚集指数显著降低[(16.65±2.45),(14.78±1.55),P<0.05];②运动后即刻时:与对照训练组相比,葛根素训练组全血黏度显著下降(P<0.05),血浆黏度显著降低[(1.75±3.3),(1.58±0.21),P<0.05],红细胞聚集指数显著下降[(21.37±4.78),(19.43±5.86),P<0.05],红细胞刚性指数显著下降[(1.58±0.90),(1.39±0.99),P<0.05],红细胞压积显著降低[(0.71±0.45),(0.57±0.43),P<0.05];③运动后恢复24h:与对照训练组相比,全血黏度、红细胞聚集指数、红细胞刚性指数、红细胞压积显著降低(P<0.05),血浆黏度差异无显著性差异[(1.45±0.47),(1.52±0.26),P>0.05]④游泳至力竭时间:葛根素组游泳时间较对照组有显著延长(P<O.05),力竭延缓率达到28%。结论:葛根素可显著改善运动大鼠血液流变性的功能,使大鼠运动能力有了明显提高。
Objective: To observe the effects of intervention of puerarin on blood hemorheology and exercise performance of rats after exercise. Method:The 60 male SD rats aged 8 weeks were selected,randomly divided two big groups: puerarin supplement groups and control groups, each group had 30 rats .each big group divided three small groups: the sedentary group, the train immediately group and the train after 24 hours recovery group, each group had 10 rats. Then established the rats exhaust-swimming train model. After puerarin supplement the exhausting-swimming time was recorded, rats' exercise performances were observed and the blood viscosity, plasma viscosity, aggregability of red blood celI(ARBC), hematocrit(HCT),erythroeyte index of rigidity(EIR),erythrocyte sedimentation rate(ESR)were mea- sured. Result: ①On sedentary time: Compared with control group , the whole blood viscosity of puerarin group declined significantly[(8.41 ± 0.76),(6.51 ±0.92), P〈0.05], the EIR declined significantly[(1.23 ±0.76),(0.98 ± 0.72), P〈0.05], the ARBC of puerarin group declined significantly[(16.65±2.45),(14.78 ± 1.55),P〈0.05];②On the train immediately: Compared with control group, the blood viscosity of puerarin group declined significantly(P〈0.05), the plasma viscosity declined significantly[(1.75± 3.3), (1.58± 0.21),P〈0.05], the ARBC of puerarin group declined significantly[(21.37 ± 4.78), (19.43 ± 5.86), P〈0.05], the EIR declined significantly [(1.58 ± 0.90),(1.39 ± 0.99), P〈0.05], the HCT of puerarin group declined significantly[(0.71±0.45),(0.57 ± 0.43),P〈0.05]; ③After 24 hours recovery: Compared with control group, the blood viscosity, ARBC, EIR, HCT of puerarin group declined significantly(P〈 0.05), the plasma viscosity of puerarin group had no significant difference[(1.45± 0.47), (1.52 ± 0.26),P〉0.05];④ The exhausted swimming time: The swimming time of the puerarin group was longer than the control group(P〈 0.05),and the Exhaustive Delay Rate Increased to 28%. Conclusion: Puerarin could effectively prolong the exhausted swimming time and improve hemorheological indices.
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2012年第7期639-642,共4页
Chinese Journal of Rehabilitation Medicine
关键词
葛根素
力竭运动
血液流变
大鼠
1ouerarin
exhausted exercise
hemorheologv
rat