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多聚腺苷酸二磷酸核糖转移酶抑制剂的放射增敏作用及机制研究

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摘要 放疗是恶性肿瘤的主要治疗手段之一,临床上约70%的恶性肿瘤患者在治疗不同阶段需接受放疗。多种细胞毒药物被用于放疗联合治疗以增加对肿瘤的治疗疗效,如氟尿嘧啶、顺铂、卡铂和丝链霉素C等,然而它们往往在增加肿瘤细胞杀伤的同时也加重了正常组织损伤,因此寻找特异性针对肿瘤的放射增敏剂是放疗研究的方向。
出处 《中华放射肿瘤学杂志》 CSCD 北大核心 2012年第4期380-383,共4页 Chinese Journal of Radiation Oncology
基金 国家自然科学基金项目(81072164)
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参考文献31

  • 1Chalmers AJ,Lakshman M,Chan N. Poly (ADP-ribose)polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets[J].Seminars in Radiation Oncology,2010.274-281.
  • 2Meyn RE,Munshi A,Haymach JV. Receptor signaling as a regulatory mechanism of DNA repair[J].Radiotherapy and Oncology,2009.316-322.
  • 3Jorgensen TJ. Enhancing radiosensitivity:targeting the DNA repair pathways[J].Cancer Biology and Therapy,2009.665-670.
  • 4Femet M,Hall J. Genetic biomarkers of therapeutic radiation sensitivity[J].Dna Repair,2004.1237-1243.
  • 5Powell C,Mikropoulos C,Kaye SB. Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers[J].Cancer Treatment Reviews,2010.566-575.
  • 6Leung M,Rosen D,Fields S. Poly(ADP-ribose) polymerase-1 Inhibition:preclinical and clinical development of synthetic lethality[J].Molecular Medicine,2011.
  • 7Drew Y,Plummer R. The emerging potential of poly(ADP-ribose)polymerase inhibitors in the treatment of breast cancer[J].Current Opinion in Obstetrics and Gynecology,2010.67-71.
  • 8Tutt A,Robson M,Garber JE. Oral poly (ADP-ribose)polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer:a proof-of-concept trial[J].The Lancet,2010.235-244.
  • 9Calabrese CR,Almassy R,Barton S. Anticancer chemosensitization and radiosensitization by the novel poly (ADP-ribose) polymerase-1 inhibitor AG14361[J].Journal of the National Cancer Institute,2004.56-67.
  • 10Albert JM,Cao C,Kim KW. Inhibition of poly(ADPribose)polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models[J].Clinical Cancer Research,2007.3033-3042.

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