福爱乐医用胶栓塞治疗颅内动静脉畸形

Clinical efficacy of embolization in treating cerebral arteriovenous malformations using a new liquid embolic agent

目的探讨福爱乐医用胶（主要成分为α-氰基丙烯酸正辛酯和仅．氰基丙烯酸正丁酯）在颅内动静脉畸形（CAVM）α-管内治疗中的临床疗效。方法局麻下经股动脉穿刺插管．微导管超选择插管至颅内病变部位，用福爱乐医用胶栓塞治疗CAVM15例。其中病灶直径大于6cm者4例，3～6cm者7例，小于3cm者4例。单支供血者3例，2支供血者5例，3支供血者7例。栓塞加手术切除3例，栓塞后行伽马刀治疗2例。结果15例患者共行26次栓塞治疗．8例获80％以上栓塞，其中5例完全栓塞；5例获50％～80％栓塞；2例栓塞小于50％。所有患者手术过程中均未发生严重粘管情况。结论福爱乐医胶治疗CAVM安全有效，是较为理想的栓塞材料。

Objective To study the clinical efficacy of embolization in treating cerebral arteriovenous malformations（AVMs） using a new liquid embolic agent, FuAiLe medical adhesive （FAL, main ingredients： α-octyl cyanoacrylate and α-butyl cyanoacrylate）. Methods Femoral artery was catheterized under local anesthesia, and then superselective catheterization to intracranial lesions were obtained using marathon 1.3F microcatheter. Fifteen cerebral AVMs were embolized by FAL. The diameter of AVMs was larger than 6 cm in 4 cases, 3-6 cm in 7 cases and smaller than 3 cm in 4 cases. Single blood supply was observed in 3 cases, 2 blood supplies in 5 cases and 3 blood supplies in 7 cases. Surgical ablation was applied after embolization in 3 cases, and gamma knife treatment was applied after embolization in 2 cases. Results A total of26-time embolization was obtained in 15 patients; more than 80% embolization was achieved in 8 cases, including 5 with complete embolization; and 50%-80% embolization was achieved in 5 cases; less than 50% embolization was achieved in only 2 cases. No serious complication associated with embolization was noted in all patients. Conclusion It is safe and effective for FAL to treat cerebral AVMs and FAL may be an ideal embolic agent.