喹硫平与利培酮治疗老年痴呆精神行为症状的临床对照研究

Clinical control study of Quetiapine and Risperidone in the treatment of behavioral and psychological symptoms of dementia

目的:比较喹硫平与利培酮治疗老年期痴呆患者精神行为症状的疗效及安全性。方法:将符合条件的52例老年痴呆伴有精神行为障碍的患者随机分为喹硫平组和利培酮组各26例,治疗8周。于治疗前及治疗后第2、4、8周分别采用阿尔茨海默病病理行为评分表(BEHAVE-AD)、药物副反应量表(TESS)评定疗效和不良反应。结果:两组BEHAVE-AD评分治疗后均显著性下降(P<0.01),治疗前后两组间BEHAVE-AD评分差异无显著性(P>0.05)。第2、4、8周时喹硫平组的TESS评分低于利培酮组,两组间差异有显著性(P<0.05)。结论:喹硫平与利培酮对治疗老年期痴呆患者精神行为症状的疗效相似,并且剂量越小安全性越高。喹硫平不良反应较利培酮少,更适用于老年患者的治疗。

Objective：To compare the efficacy and safety of Quetiapine and Risperidone in the treatment of behavioral and psychological symptoms of dementia（BPSD）. Methods ：52 patients with BPSD were randomly divided into the Quetiapine group （26 cases） and the Risperidone group （26 cases） ,treatment for 8 weeks. Before treatment and in the 2~d ,4th, 8th weekscnd, the efficacy were evaluated with the Behavioral pathology in Alzheimer disease rating scale （Behave AD）, the side effects were assessed with Treatment Emergent Symptom Scale （TESS）. Results：After treatment the Behave AD scores in the both groups decreased significantly（ P 〈 0.01 ）. There was no significant difference between the two groups （P 〉 0.05 ）. The TESS scores of the Quetiapine group was lower than the Risperdone group, there was significant difference （ P 〈 0.05 ）. Conclusion： Quetiapine and Risperidone have sim- ilar therapeutic effects in the treatment of BPSD, the doses is fewer the safety is higher. The adverse reactions of Quetiapine are less than Risperidone, more adapted to the treatment of elderly patients.