前列腺素E1治疗原发性肾病综合征并急性肾衰竭临床观察

The clinical efficacy of Prostaglandin E1 on treatment of primary nephrotic syndrome complicating with acute renal failure

目的观察前列腺素E1治疗原发性肾病综合征(PNS)并急性肾衰竭(AFR)的疗效。方法我院2006～2011年收治412例原发性肾病综合征,其中并发急性肾衰竭30例,随机分为对照组15例及治疗组15例。对照组常规治疗,治疗组在常规治疗基础上,给予前列腺素E1静脉滴注14天。观察两组发生少尿例数、血液透析例数、尿蛋白、血尿素氮、血肌酐等指标变化。结果治疗组比对照组在发生少尿及血液透析例数、血尿素氮、血肌酐等均显著减少(P<0.05);尿蛋白无显著变化(P>0.05)。结论前列腺素E1治疗肾病综合征并急性肾衰竭疗效确切,优于常规疗法,且经济实用,不良反应小。

Objective To evaluate the clinical efficacy of Prostaglandin E1 on treatment of primary nephrotic syndrome complicating with acute renal failure. Methods 30 patients with acute renal failure cases 412 hospital patients with primary nephrotic syndrome （PNS）fr om 2006 to 2011 in our hospital were randomly assigned to two treatment groups：the control group （15 cases）and the treatment group（ 15 cases）. The control group only received the basis of conventional therapy, but the treat- ment group received Prostaglandin E1 on infusion for 14 days on the basis of conventional therapy. Amount of oliguria and hemodialysis patients were observed. Urinary protein, blood urea nitrogen and serum creatinine were measured both the two groups at the end of the treatment. Results Oliguric patients, hemodialysis patients, blood urea nitrogen, and serum ereatinine in the treatment group significantly reduced compare to control group（P〈0.05 ）. No significant difference in urinary protein found between the two groups（P〉0.05）. Conclusion Prostaglandin E1 on treatment of nephrotic syndrome complicating with acute re- nal failure is superior to conventional therapy. It is effective, economical practical and lower side effects.