加巴喷丁与普瑞巴林治疗带状疱疹后神经痛的效果比较

Therapetic effect of gabapentin and pregabalin on post-herpetic neuralgia

目的观察加巴喷丁和普瑞巴林治疗带状疱疹后神经痛(post-herpetic neuralgia,PHN)的效果以及对患者睡眠的影响。方法 60例PHN患者按随机数字表法分为加巴喷丁组和普瑞巴林组各30例,分别给予加巴喷丁900 mg/d口服和普瑞巴林150 mg/d口服,疗程均为28天。观察治疗前后疼痛和睡眠的改善情况及药物不良反应。结果两组患者治疗后各时点与治疗前相比疼痛评分随时间下降,睡眠时间增加(P<0.05);普瑞巴林组治疗后各时点的疼痛视觉模拟评分(Visualanalogue scale,VAS)低于加巴喷丁组(P<0.05),24小时睡眠时间大于加巴喷丁组(P<0.05);两组未出现严重的药物不良反应,普瑞巴林组嗜睡发生率明显低于加巴喷丁组(P<0.05),其余不良反应发生率两组间比较差异均无统计学意义(P>0.05)。结论普瑞巴林治疗PHN更安全有效,优于加巴喷丁。

Objective To observe the＇efficacy of gabapentin and pregabalin in the treatment of post-herpetic neuralgia （PHN）. Methods Sixty patients suffering from PHN were randomly divide into the gabapentin group and pregabalin group. The gabapentin group were treated by gabapentin 900 mg/d for oral use and the pregabalin group were treated by pregabalin 150 mg/d for oral use. The period of both the two groups were 28 days. Before and after treatment, symptoms and signs of neuropathy including pain sleeping were observed The side effects and complications were observede. Results The vas score of both groups in each times was lower than before treatment （ P 〈 0.05 ） and the sleeping time was increased （ P 〈 0.05 ）. The vas score of pregabalin group in the T2, T3, T4,T5, T6,T7 was lower than the gabapentin group（ P 〈 0.05 ）. There were no severe drug adverse reaction in both groups. The incidences rate of drowsiness in pregabalin group was lower than the gabapentin group （ P 〈 0.05 ）. There was no significant other adverse reaction between the two groups. Conclusion Gregabalin was much safe and effective in the treatment of PHN than gabapentin.