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Wld^s基因轴突保护作用机制的研究进展

The protection mechanism of Wlds genes in the procedure of axonal damage
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摘要 Wlds(Wallerian degeneration-slow)基因是位于小鼠4号染色体远端85 kb单元的串联三重嵌合基因。Wlds基因编码的融合蛋白由N端70个氨基酸的泛素因子E4-Ube4b(同源酵母Ufd)的片段和C段NAD+合成酶尼克酰胺转移酶1(Nmnat1)以及中间18个氨基酸的联结组成。研究显示Wlds基因能延缓神经轴突的损伤,对视神经炎等神经退行性疾病具有保护作用,然而其机制尚不清楚。本文对Wlds基因轴突保护作用的可能机制:烟酰胺单核苷酸腺苷酰转移酶1(Nmnat1)相关的烟酰胺腺嘌呤二核苷酸(NAD)的生物合成、泛素化依赖的蛋白酶体系统、受损轴突中炎症细胞的浸润、相应调节蛋白酶的表达及活性、Wlds保护作用的时间点等几个方面进行概括和总结。
作者 王波 蒋沁
机构地区 南京医科大学附属眼科医院
出处 《实用医院临床杂志》 2012年第4期210-213,共4页 Practical Journal of Clinical Medicine
基金 国家自然科学基金资助项目(编号:81070744)
关键词 Wld S基因 华勒变性 神经退行性变 轴突保护作用
分类号 R322.81 [医药卫生—人体解剖和组织胚胎学] R394.21 [医药卫生—医学遗传学]
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参考文献38

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实用医院临床杂志
2012年 第4期

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