过量碘对仔鼠海马组织乙酰胆碱酯酶的影响

Effects of excess iodine on acetylcholinesterase activity in hippocampus of young mice

目的 观察长期过量碘的摄入对仔鼠神经系统的影响。方法 用高碘水复制出高碘甲状腺肿动物模型 ,采用动力学法对高碘甲状腺肿小鼠子一代 (F1 )、子二代 (F2 ) 15、30日龄仔鼠脑内海马组织乙酰胆碱酯酶(ACHE)的活性进行了测定。结果 高碘组 F1 代、F2代 15日龄仔鼠 ACHE活性均较对照组升高 ,F2 与 F1 代仔鼠相比 ,ACHE活性无明显差别。结论 在脑发育临界期 ,过量碘的摄入可使脑内 ACHE活性升高 ,使脑内胆碱能系统受到影响 ,导致学习。

Objective Observe the influence of excessive intake of iodine on nerve system of young mice.Methods Animal of goiter was reconstructed in mice by feeding them with water containing high level of iodine for three months.Activities of ACHE in hippocampus were measured in 15、30 day young mice of F 1 generation and F 2 generation.Results The activities of ACHE in high iodine were significantly higher than those in moderate iodine control in 15 day old young mice.Conclusions It suggests that excessive intake of iodine might affect the abilities of learning and memory during the critical period of brain development in mice. [