仿根治术治疗Ⅱ期乳腺癌远期疗效分析

Long-term effects of modified radical mastectomy for stage Ⅱ breast cancer.

目的 总结Ⅱ期乳腺癌采用仿根治术治疗的远期效果。方法 346例Ⅱ期乳腺癌 ,采用仿根治术(MRM组 ) 2 95例 ,其中仿根治术Ⅰ式 (MRMⅠ组 ) 174例 ,仿根治术Ⅱ式 (MRMⅡ组 ) 12 1例 ,标准根治术 (Halsted手术 ,HRM组 ) 5 1例。治疗后随访 8年以上。比较各种手术术式与病人生存率的关系。结果 MRM和HRM两组病人 8年总生存率分别为 73 9%和 70 6 % ,差异无显著意义。在淋巴结阳性病人中 ,MRMⅡ组生存率高于MRMⅠ组 (分别为 73 %和 5 1% ,P <0 0 1)。结论 Ⅱ期乳腺癌采用仿根治术治疗 ,远期效果同Halsted根治术。

Objective\ Summarize the long-term therapeutic results of modified radical mastectomy(MRM)for stage Ⅱ breast cancer.Methods\ 346 females with stage Ⅱ breast cancer were treated with surgical operation.295 were treated with modified radical mastectomy(group MRM):type Ⅰ of MRM(MRM Ⅰ)174 cases and type Ⅱ of MRM(MRM Ⅱ)121 cases.51 cases were treated with Halsted radical mastectomy.Follow-up of all cases were at least for 8 years.Compare the relationship between the operation style and the survival rate.Results\ The 8-year survival rate were 73 9% and 70 6%,respectively in groups MRM and HRM,and no significant differences existed between the two groups.But the 8-year survival rate of patients with node-positive in the group MRM Ⅱ was 73%, which was higher than that of patients with node-positive in the group MRM Ⅰ (51%)(P<0 01).Conclusion\ The long-term therapeutic results of modified radical mastectomy were the same as Halsted radical mastectomy for stage Ⅱ breast cancer.Patients with node-positive are suitable for using type Ⅱ of MRM.