分泌性中耳炎患者免疫状态及耳积液NO、IFN-γ、IL-2的变化研究

Study on the change of immune state and ear effusion NO,IFN-γ,IL-2 of patients with secretory otitis media

目的探讨分泌性中耳炎患者免疫状态及耳积液一氧化氮（NO）、人γ干扰素（IFN-γ）、人白介素2（IL-2）的变化规律。方法选取2009年4月~2011年11月于本院进行治疗的36例分泌性中耳炎患者为观察组,同期的36例健康人员为对照组,后将两组人员的外周血T淋巴细胞亚群、免疫球蛋白及耳积液NO、IFN-γ、IL-2水平进行比对。结果观察组的外周血T淋巴细胞亚群中的CD8＋、免疫球蛋白均高于对照组,外周血T淋巴细胞亚群中的CD3＋、CD4＋及CD4/CD8则均低于对照组,耳积液NO、IFN-γ、IL-2均高于对照组,且慢性患者差异幅度更大（均P〈0.05）。结论分泌性中耳炎患者免疫状态及耳积液NO、IFN-γ、IL-2的变化规律对于了解疾病情况有着积极的作用。

Objective To study the variation of immune state and ear effusion NO, IFN-γ、IL-2 of patients with secretory otitis media. Methods 36 patients with secretory otitis media in our hospital from April 2009 to November 2011 were se- lected as observation group, and 36 healthy staff at the same time were selected as control group, then the peripheral blood T lymphocyte subsets, immunoglobulin and ear effusion NO, IFN-% IL-2 of two groups were compared. Results The CD8^＋ of peripheral blood T lymphocyte subsets and immunoglobulin of observation group were all higher than those of control group, CD3＋, CD4＋ and CD4/CD8 of peripheral blood T lymphocyte subsets were all lower than those of control group, ear effusion NO, IFN-γ IL-2 were all higher than those of control group, and the differences of chronic patients were bigger than those of acute patients （all P 〈 0.05）. Conclusion The variation of immune state and ear effusion NO, IFN-γ IL-2 of patients with secretory otitis media plays an active role in understanding the situation of disease.