鳞状上皮细胞癌抗原和HPV-DNA联合检测对宫颈癌诊断的临床意义

The clinical significance of squamous cell carcinoma antigen and HPV-DNA joint detection in diagnosis of cervical cancer

目的研究鳞状上皮细胞癌抗原(SCC-AG)和HPV基因分型联合检测对宫颈癌诊断的临床意义。方法对到本院就诊的宫颈病变患者采取SCC-AG及HPV基因分型检测,将单纯SCC-AG检测的阳性率及HPV基因分型检测阳性率分别与联合检测结果进行对比。结果 SCC-AG检测阳性率为11.21%,准确率为64.62%;HPV-DNA检测阳性率为14.31%,准确率为73.49%;联合检测阳性率为10.00%,准确率为94.83%。单纯HPV-DNA检测阳性率与联合检测阳性率相比,差异有统计学意义(P<0.05)。结论 SCC-AG和HPV基因分型联合检测可明显提高宫颈癌的检出率,避免漏诊与误诊,对于宫颈癌的临床诊断具有重要的临床指导意义。

Objective To study the clinical significance of squamous cell carcinoma antigen （SCC-AG） and HPV genotyp- ing joint detection in diagnosis of cervical cancer. Methods Patients with cervical lesions treated in our hospital were adopted squamous cell carcinoma antigen （SCC-AG） and HPV genotyping detection. The positive rate of the simply detec- tion of SCC-AG and HPV genotyping were compared with the joint test results. Results The positive rate of SCC-AG de- tection was 11.21%, the accuracy rate was 64.62%. The positive rate of HPV-DNA detection was 14.31%, the accuracy rate was 73.49%%. The positive rate of joint detection was 10.00%, the accuracy rate was 94.83%. The positive rate be- tween the simply HPV-DNA detection and the joint detection was compared, the difference was statistically significant （P 〈 0.05）. Conclusion SCC-AG and HPV-DNA joint detection can significantly improve the detection rate of cervical can- cer, avoid missed diagnosis and misdiagnosis, it has important clinical significance for the clinical diagnosis of cervical can- cer.