来氟米特治疗狼疮性肾炎的疗效观察

Clinical Observation on the Effect of Ieflunomide in Treating Lupus Nephritis

目的观察来氟米特对60例狼疮性肾炎患者的临床疗效。方法选择我院2007年1月到2011年2月我院收治的60例狼疮性肾炎患者,将患者随机分为观察组和对照组两组,观察组采取来氟米特治疗,对照组使用CTX治疗,观察患者主观感受和各种客观临床指标。结果对于疗效比较,两组有效率的差异没有统计学意义(P>0.05);其它各种指标当中尿蛋白定量、ANA和ds-DNA在治疗前后的差异有统计学意义(P<0.05);而血清蛋白、C3、C4的数值两组之间的差异则不具有统计学意义(P>0.05)。结论和CTX相比较,来氟米特较在治疗狼疮性肾炎患者上不但能保证治疗效果,还具有更高的安全性和更为经济实惠,值得临床推广应用。

Objective To observe the clinical curative effect of leflunomide on 60 patients with lupus nephritis. Methods 60 patients with lupus nephritis in our hospital from January 2007 to February 2011 were selected and randomly divided into observation group and control group. Patients in the observation group were treated with the leflunomide, while patients in the control group received the CTX treatment. The patients＇ subjective feelings and objective clinical indices in the two groups were observed and compared. Results The difference of curative effect between the observation group and the control group had no statistical significance （P 0.05）. The difference of urinary protein, ANA and ds-DNA between preoperation and postoperation had statistical significance （P 0.05）. The difference of haemocyanin, C3, C4 between the two groups had no statistical significance （P 0.05）. Conclusions Compared with the CTX, leflunomide in the treatment of lupus nephritis can not only guarantee the therapeutic effect, but also have better security and more economic benefits, which is worthy of clinical popularizion and application.