128例绝经后发生反复下尿路感染病人的临床诊治分析

Clinical Diagnosis and Treatment of Repeated Low Urinary Tract Infection in 128 Postmenopausal Women

目的分析并总结女性绝经后发生反复下尿路感染的有效治疗方法。方法对我院自2010年6月至2011年12月期间收治的128例绝经后反复下尿路感染病人长时间给予小剂量抗生素,并配合使用α-受体阻滞剂及雌激素实施治疗。结果经治疗后,全部128例病人中总有效115例(89.84%),其中78例(60.94%)为痊愈,23例(17.97%)为显效,14例(10.94%)为改善,13例(10.16%)为无效。11例病人口服坦索罗辛缓释胶囊发生程度不等的恶心、头晕、头痛、心慌以及体位性低血压等反应,但均出现于服药早期,症状均较轻微,通过减量后病人反应减轻并消失,未对病人的继续治疗产生影响。结论对绝经后发生反复下尿路感染病人长时间给予小剂量抗生素,并配合使用α-受体阻滞剂及雌激素等综合疗法实施治疗可以得到令人满意的临床疗效,值得临床广泛推广并应用。

Objective To analyze and summarize the effective treatment methods for repeated low urinary tract infection in postmenopausal women. Methods 128 postmenopausal women with repeated low urinary tract infection in our hospital from June 2010 to December 2011 were treated with low-dosage antibiotics for long duration, together with α-receptor antagonist and estrogen. Results The total effective rate was 89.84% （115 cases） with 78 cases （60.94%） of cure, 23 cases （17.97%） of effectiveness, 14 cases （10.94%） of improvement and 13 cases （10.16%） of ineffectiveness. 11 patients had side effects such as nausea, dizziness, headaches, palpitation and postural hypotension with hydrochloride sustained-release capsules by oral, and the reactions eased and disappeared when dosage reduced. Conclusions The comprehensive therapy of low-dosage antibiotics for long duration together with α-receptor antagonist and estrogen has good clinical curative effect in treatment of repeated low urinary tract infection in postmenopausal women, which is worthy of clinical application.